ABSTRACT
Delay discounting (DD), or the tendency to favor immediate over future rewards, is a form of impulsivity that is present in a constellation of diseases. Here we performed a genome-wide association study of DD using 23,127 research participants of European ancestry. We estimated chip heritability at 12%, and identified significant genetic correlations between DD and neuropsychiatric diseases (attention-deficit/hyperactivity disorder (ADHD), schizophrenia, major depression), smoking, personality, cognition, and weight.
Footnotes
Collaborator List for the 23andMe Research Team Michelle Agee, Babak Alipanahi, Adam Auton, Robert K. Bell, Katarzyna Bryc, Sarah L. Elson, Pierre Fontanillas, Nicholas A. Furlotte, David A. Hinds, Bethann S. Hromatka, Karen E. Huber, Aaron Kleinman, Nadia K. Litterman, Matthew H. McIntyre, Joanna L. Mountain, Carrie A.M. Northover, J. Fah Sathirapongsasuti, Olga V. Sazonova, Janie F. Shelton, Suyash Shringarpure, Chao Tian, Joyce Y. Tung, Vladimir Vacic, Catherine H. Wilson, Steven J. Pitts