RT Journal Article
SR Electronic
T1 A model for adult organ resizing demonstrates stem cell scaling through a tunable commitment rate
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 137638
DO 10.1101/137638
A1 XinXin Du
A1 Lucy Erin O’Brien
A1 Ingmar Riedel-Kruse
YR 2017
UL http://biorxiv.org/content/early/2017/05/13/137638.abstract
AB Many adult organs grow or shrink to accommodate different physiological demands. Often, as total cell number changes, stem cell number changes proportionally in a phenomenon called ‘stem cell scaling’. The cellular behaviors that give rise to scaling are unknown. Here we study two complementary theoretical models of the adult Drosophila midgut, a stem cell-based organ with known resizing dynamics. First, we derive a differential equations model of midgut resizing and show that the in vivo kinetics of growth can be recapitulated if the rate of fate commitment depends on the tissue’s stem cell proportion. Second, we develop a twodimensional simulation of the midgut and find that proportion-dependent commitment rate and stem cell scaling can arise phenomenologically from the stem cells’ exploration of physical tissue space during its lifetime. Together, these models provide a biophysical understanding of how stem cell scaling is maintained during organ growth and shrinkage.