RT Journal Article SR Electronic T1 In depth analysis of kinase cross screening data to identify chemical starting points for inhibition of the nek family of kinases JF bioRxiv FD Cold Spring Harbor Laboratory SP 137968 DO 10.1101/137968 A1 Carrow I. Wells A1 Nirav R. Kapadia A1 Rafael M. Couñago A1 David H. Drewry YR 2017 UL http://biorxiv.org/content/early/2017/05/14/137968.abstract AB Potent, selective, and cell active small molecule kinase inhibitors are useful tools to help unravel the complexities of kinase signaling. As the biological functions of individual kinases become better understood, they can become targets of drug discovery efforts. The small molecules used to shed light on function can also then serve as chemical starting points in these drug discovery efforts. The Nek family of kinases has received very little attention, as judged by number of citations in PubMed, yet they appear to play many key roles and have been implicated in disease. Here we present our work to identify high quality chemical starting points that have emerged due to the increased incidence of broad kinome screening. We anticipate that this analysis will allow the community to progress towards the generation of chemical probes and eventually drugs that target members of the Nek family.