RT Journal Article
SR Electronic
T1 Discovery of the first genome-wide significant risk loci for ADHD
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 145581
DO 10.1101/145581
A1 Ditte Demontis
A1 Raymond K. Walters
A1 Joanna Martin
A1 Manuel Mattheisen
A1 Thomas D. Als
A1 Esben Agerbo
A1 Rich Belliveau
A1 Jonas Bybjerg-Grauholm
A1 Marie Bækvad-Hansen
A1 Felecia Cerrato
A1 Kimberly Chambert
A1 Claire Churchhouse
A1 Ashley Dumont
A1 Nicholas Eriksson
A1 Michael Gandal
A1 Jacqueline Goldstein
A1 Jakob Grove
A1 Christine S. Hansen
A1 Mads E. Hauberg
A1 Mads V. Hollegaard
A1 Daniel P. Howrigan
A1 Hailiang Huang
A1 Julian Maller
A1 Alicia R. Martin
A1 Jennifer Moran
A1 Jonatan Pallesen
A1 Duncan S. Palmer
A1 Carsten B. Pedersen
A1 Marianne G. Pedersen
A1 Timothy Poterba
A1 Jesper B. Poulsen
A1 Stephan Ripke
A1 Elise B. Robinson
A1 Kyle F. Satterstrom
A1 Christine Stevens
A1 Patrick Turley
A1 Hyejung Won
A1 ADHD Working Group of the Psychiatric Genomics Consortium (PGC), Early Lifecourse & Genetic Epidemiology (EAGLE) Consortium, 23andMe Research Team
A1 Ole A. Andreassen
A1 Christie Burton
A1 Dorret Boomsma
A1 Bru Cormand
A1 Søren Dalsgaard
A1 Barbara Franke
A1 Joel Gelernter
A1 Daniel Geschwind
A1 Hakon Hakonarson
A1 Jan Haavik
A1 Henry Kranzler
A1 Jonna Kuntsi
A1 Kate Langley
A1 Klaus-Peter Lesch
A1 Christel Middeldorp
A1 Andreas Reif
A1 Luis A. Rohde
A1 Panos Roussos
A1 Russell Schachar
A1 Pamela Sklar
A1 Edmund Sonuga-Barke
A1 Patrick F. Sullivan
A1 Anita Thapar
A1 Joyce Tung
A1 Irwin Waldman
A1 Merete Nordentoft
A1 David M. Hougaard
A1 Thomas Werge
A1 Ole Mors
A1 Preben B. Mortensen
A1 Mark J. Daly
A1 Stephen V. Faraone
A1 Anders D. Børglum
A1 Benjamin M. Neale
YR 2017
UL http://biorxiv.org/content/early/2017/06/03/145581.abstract
AB Attention-Deficit/Hyperactivity Disorder (ADHD) is a highly heritable childhood behavioral disorder affecting 5% of school-age children and 2.5% of adults. Common genetic variants contribute substantially to ADHD susceptibility, but no individual variants have been robustly associated with ADHD. We report a genome-wide association meta-analysis of 20,183 ADHD cases and 35,191 controls that identifies variants surpassing genome-wide significance in 12 independent loci, revealing new and important information on the underlying biology of ADHD. Associations are enriched in evolutionarily constrained genomic regions and loss-of-function intolerant genes, as well as around brain-expressed regulatory marks. These findings, based on clinical interviews and/or medical records are supported by additional analyses of a self-reported ADHD sample and a study of quantitative measures of ADHD symptoms in the population. Meta-analyzing these data with our primary scan yielded a total of 16 genome-wide significant loci. The results support the hypothesis that clinical diagnosis of ADHD is an extreme expression of one or more continuous heritable traits.