PT - JOURNAL ARTICLE AU - Alexey V. Shvetsov AU - Yana A. Zabrodskaya AU - Peter A. Nekrasov AU - Vladimir V. Egorov TI - Triazavirine supramolecular complexes as modifiers of the peptide oligomeric structure AID - 10.1101/150664 DP - 2017 Jan 01 TA - bioRxiv PG - 150664 4099 - http://biorxiv.org/content/early/2017/06/16/150664.short 4100 - http://biorxiv.org/content/early/2017/06/16/150664.full AB - In this study we present molecular dynamics simulations of the antiviral drug triazavirine, that affects formation of amyloid-like fibrils of the model peptide (SI). According to our simulations, triazavirine is able to form linear supramolecular structures which can act as shields and prevent interactions between SI monomers. This model, as validated by simulations, provides an adequate explanation of triazavirine’s mechanism of action as it pertains to SI peptide fibril formation.