RT Journal Article
SR Electronic
T1 Significant metabolic improvement by a water extract of olives: animal and human evidence
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 151860
DO 10.1101/151860
A1 Nikolaos Peroulis
A1 Vasilis P. Androutsopoulos
A1 George Notas
A1 Stella Koinaki
A1 Elsa Giakoumaki
A1 Apostolos Spyros
A1 Εfstathia Manolopoulou
A1 Sophia Kargaki
A1 Maria Tzardi
A1 Eleni Moustou
A1 Euripides G. Stephanou
A1 Efstathia Bakogeorgou
A1 Niki Malliaraki
A1 Maria Niniraki
A1 Christos Lionis
A1 Elias Castanas
A1 Marilena Kampa
YR 2017
UL http://biorxiv.org/content/early/2017/06/19/151860.abstract
AB Dyslipidemia and impaired glucose metabolism, are main health issues of growing prevalence and significant high Health Care cost, requiring novel prevention and/or therapeutic approaches. Epidemiological and animal studies revealed olive oil as an important dietary constituent for normolipidemia. However, no studies have specifically investigated the polyphenol rich water extract of olives (OLWPE), generated during olive oil production. Here, we explore OLPWE in animals and human metabolic parameters. High fat-fed rats developed a metabolic dysfunction, which was significantly impaired when treated with OLWPE, with decreased LDL and insulin levels and increased HDL. Moreover, they increased total plasma antioxidant capacity, while several phenolic compounds were detected in their blood. These findings were also verified in humans that consumed OLWPE daily for four weeks in a food matrix. Our data clearly show that OLWPE can improve glucose and lipid profile, indicating its possible use in the design of functional food and/or therapeutic interventions.