PT  - JOURNAL ARTICLE
AU  - Milsee Mol
AU  - Dipali Kosey
AU  - Ramanamurthy Bopanna
AU  - Shailza Singh
TI  - Transcription Factor Target Gene Network governs the Logical Abstraction Analysis of the Synthetic Circuit in Leishmaniasis
AID  - 10.1101/151779
DP  - 2017 Jan 01
TA  - bioRxiv
PG  - 151779
4099  - http://biorxiv.org/content/early/2017/06/19/151779.short
4100  - http://biorxiv.org/content/early/2017/06/19/151779.full
AB  - Stochastic variations in the transcription factor target gene network influences the dynamics of protein levels. The mathematical model built, here, is useful to study the cytokine response and the resulting dynamical patterns in leishmaniasis. The fluctuations produced affect the expression rate of its target in the regulatory synthetic circuit designed by means of a negative feedback loop insertion. Thus, the faster the response time, smaller is the fluctuation of the system observed and it can be justified that the TFTG network embedded can be understood with the recurring dynamics of the designed synthetic circuit. List of AbbreviationsTFtranscription factorPPARαperoxisome proliferator-activated receptor-FAsfatty acidsDCsdendritic cellsTFTG networkTranscription Factor Target Gene NetworkIFNginterferon gVLvisceral leishmaniasisCLcutaneous leishmaniasisG-MCFgranulocyte macrophage colony-stimulating factorILinterleukinPKCProtein Kinase CPBCPeriodic boundary conditionNPTNormal Pressure temperatureNVTNormal Volume TemperatureMDMolecular DynamicsRMSDroot mean square deviationRMSFroot mean square fluctuationLBLuria BerttiniIInfectionCTChimeric PKCCTIChimeric PKC + InfectionCTMChimeric PKC + MiltefosineCTIMChimeric PKC + Infection + MiltefosineCCCloseness centralityIPTGIsopropyl β-D-1-thiogalactopyranoside