RT Journal Article
SR Electronic
T1 Delineating the macroscale areal organization of the macaque cortex in vivo
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 155952
DO 10.1101/155952
A1 Ting Xu
A1 Arnaud Falchier
A1 Elinor L. Sullivan
A1 Gary Linn
A1 Julian Ramirez
A1 Deborah Ross
A1 Eric Feczko
A1 Alexander Opitz
A1 Jennifer Bagley
A1 Darrick Sturgeon
A1 Eric Earl
A1 Oscar Miranda-Domingue
A1 Anders Perrone
A1 Cameron Craddock
A1 Charles Schroeder
A1 Stan Colcombe
A1 Damien Fair
A1 Michael Milham
YR 2017
UL http://biorxiv.org/content/early/2017/06/26/155952.abstract
AB Complementing longstanding traditions centered around histology, functional magnetic resonance imaging approaches are rapidly maturing in their ability to delineate brain areal organization at the macroscale. In particular, automated approaches focused on the detection of gradient-based boundaries in functional connectivity (FC) properties between cortical areas have demonstrated the ability to characterize human brain organization at the individual level and recapitulate previously established cytoarchitectonic brain areas. The use of non-human primates (NHP) provides the opportunity to overcome critical barriers in the advancement of translational research. Here, we establish the data and scanning condition requirements for achieving reproducible, stable and internally valid areal parcellations at the individual levels, which have good correspondences with previously established postmortem areas; the inclusion of data from two independent imaging sites ensures the reproducibility of our findings. We demonstrate that highly reproducible areal organizations that can be used for fingerprinting can be achieved whether subjects were scanned under anesthesia or awake (rest, naturalistic viewing); though differences between awake and anesthetized states precluded the detection of individual differences across states; individual differences were notably more stable across differing awake states. Comparison of awake and anesthetized states suggested a more nuanced picture of changes in connectivity for higher order association areas, as well as visual cortex. These results establish feasibility and data requirements for the generation of reproducible individual-specific parcellations in NHP, as well provide insights into the impact of scan state on findings.