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Page 1
A novel heteromeric pantothenate kinase complex in apicomplexan parasites.
PLoS Pathog. 2021 Jul 29;17(7):e1009797. doi: 10.1371/journal.ppat.1009797. eCollection 2021 Jul.
PLoS Pathog. 2021.
PMID: 34324601
Free PMC article.
Pantothenate biosynthesis in Toxoplasma gondii tachyzoites is not a drug target.
Howieson VM, Zeng J, Kloehn J, Spry C, Marchetti C, Lunghi M, Varesio E, Soper A, Coyne AG, Abell C, van Dooren GG, Saliba KJ.
Howieson VM, et al.
Int J Parasitol Drugs Drug Resist. 2023 Aug;22:1-8. doi: 10.1016/j.ijpddr.2023.03.003. Epub 2023 Mar 15.
Int J Parasitol Drugs Drug Resist. 2023.
PMID: 37004488
Free PMC article.
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Exploring Heteroaromatic Rings as a Replacement for the Labile Amide of Antiplasmodial Pantothenamides.
Guan J, Spry C, Tjhin ET, Yang P, Kittikool T, Howieson VM, Ling H, Starrs L, Duncan D, Burgio G, Saliba KJ, Auclair K.
Guan J, et al. Among authors: howieson vm.
J Med Chem. 2021 Apr 22;64(8):4478-4497. doi: 10.1021/acs.jmedchem.0c01755. Epub 2021 Apr 1.
J Med Chem. 2021.
PMID: 33792339
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Mutations in the pantothenate kinase of Plasmodium falciparum confer diverse sensitivity profiles to antiplasmodial pantothenate analogues.
Tjhin ET, Spry C, Sewell AL, Hoegl A, Barnard L, Sexton AE, Siddiqui G, Howieson VM, Maier AG, Creek DJ, Strauss E, Marquez R, Auclair K, Saliba KJ.
Tjhin ET, et al. Among authors: howieson vm.
PLoS Pathog. 2018 Apr 3;14(4):e1006918. doi: 10.1371/journal.ppat.1006918. eCollection 2018 Apr.
PLoS Pathog. 2018.
PMID: 29614109
Free PMC article.
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Structure-Activity Relationships of Antiplasmodial Pantothenamide Analogues Reveal a New Way by Which Triazoles Mimic Amide Bonds.
Guan J, Tjhin ET, Howieson VM, Kittikool T, Spry C, Saliba KJ, Auclair K.
Guan J, et al. Among authors: howieson vm.
ChemMedChem. 2018 Dec 20;13(24):2677-2683. doi: 10.1002/cmdc.201800327. Epub 2018 Nov 29.
ChemMedChem. 2018.
PMID: 30370998
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Triazole Substitution of a Labile Amide Bond Stabilizes Pantothenamides and Improves Their Antiplasmodial Potency.
Howieson VM, Tran E, Hoegl A, Fam HL, Fu J, Sivonen K, Li XX, Auclair K, Saliba KJ.
Howieson VM, et al.
Antimicrob Agents Chemother. 2016 Nov 21;60(12):7146-7152. doi: 10.1128/AAC.01436-16. Print 2016 Dec.
Antimicrob Agents Chemother. 2016.
PMID: 27645235
Free PMC article.
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