Although human tumours are shaped by the genetic evolution of cancer cells, evidence also
suggests that they display hierarchies related to developmental pathways and epigenetic …

Background The Raymond–Roy Occlusion Classification (RROC) is the standard for
evaluating coiled aneurysms (Class I: complete obliteration; Class II: residual neck; Class III: …

To understand the pathogenesis of chronic inflammatory disease, we analyzed an
experimental mouse model of chronic lung disease with pathology that resembles asthma and …

Poly(ADP-ribose) polymerase (PARP) inhibitors are strikingly toxic to cells with defects in
homologous recombination (HR). The mechanistic basis for these findings is incompletely …

OBJECTIVES: The diagnosis of cholangiocarcinoma is often difficult, making management
approaches problematic. A reliable serum tumor marker for cholangiocarcinoma would be a …

Single-cell genomics is essential to chart tumor ecosystems. Although single-cell RNA-Seq (scRNA-Seq)
profiles RNA from cells dissociated from fresh tumors, single-nucleus RNA-Seq …

Chronic obstructive lung disease is characterized by persistent abnormalities in epithelial and
immune cell function that are driven, at least in part, by infection. Analysis of parainfluenza …

Clean and safe water is a fundamental human need for multi-faceted development of
society and a thriving economy. Brisk rises in populations, expanding industrialization, …

Host defense against viruses probably depends on targeted death of infected host cells and
then clearance of cellular corpses by macrophages. For this process to be effective, the …

Epithelial hyperplasia and metaplasia are common features of inflammatory and neoplastic
disease, but the basis for the altered epithelial phenotype is often uncertain. Here we show …