Ischaemia-reperfusion injury occurs when the blood supply to an organ is disrupted and then
restored, and underlies many disorders, notably heart attack and stroke. While reperfusion …

Oxidative damage from elevated production of reactive oxygen species (ROS) contributes to
ischemia-reperfusion injury in myocardial infarction and stroke. The mechanism by which …

Motivation: The myGrid project aims to exploit Grid technology, with an emphasis on the
Information Grid, and provide middleware layers that make it appropriate for the needs of …

Brown and beige adipose tissues can dissipate chemical energy as heat through thermogenic
respiration, which requires uncoupling protein 1 (UCP1) 1 , 2 . Thermogenesis from these …

The citric acid cycle (CAC) metabolite fumarate has been proposed to be cardioprotective;
however, its mechanisms of action remain to be determined. To augment cardiac fumarate …

Many copies of mammalian mitochondrial DNA contain a short triple-stranded region, or
displacement loop (D-loop), in the major noncoding region. In the 35 years since their discovery…

Mitochondrial carriers link biochemical pathways in the cytosol and mitochondrial matrix by
transporting substrates across the inner mitochondrial membrane. Substrate recognition is …

The structures of mitochondrial transporters and uncoupling proteins are 3-fold pseudosymmetrical,
but their substrates and coupling ions are not. Thus, deviations from symmetry are to …

Complex I has reactive thiols on its surface that interact with the mitochondrial glutathione
pool and are implicated in oxidative damage in many pathologies. However, the Cys residues …

Mitochondrial proteins remain the subject of intense research interest due to their implication
in an increasing number of different conditions including mitochondrial and metabolic …