Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain
largely elusive. To identify genetic loci for obesity susceptibility, we examined associations …

Plasma concentrations of total cholesterol, low-density lipoprotein cholesterol, high-density
lipoprotein cholesterol and triglycerides are among the most important risk factors for …

Background Silent brain infarcts are frequently seen on magnetic resonance imaging (MRI)
in healthy elderly people and may be associated with dementia and cognitive decline. …

In this paper the Rotterdam Elderly Study is presented. The aim of the study is to investigate
determinants of disease occurrence and progression in the elderly. In addition to …

High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease.
We report the largest genetic association study of blood pressure traits (systolic, diastolic …

Atrial fibrillation is a highly prevalent arrhythmia and a major risk factor for stroke, heart failure
and death 1 . We conducted a genome-wide association study (GWAS) in individuals of …

Blood pressure is a major cardiovascular disease risk factor. To date, few variants associated
with interindividual blood pressure variation have been identified and replicated. Here we …

We performed a meta-analysis of 14 genome-wide association studies of coronary artery
disease (CAD) comprising 22,233 individuals with CAD (cases) and 64,762 controls of …

Background Noninvasive assessment of intima-media thickness (IMT) is widely used in
observational studies and trials as an intermediate or proxy end point for cardiovascular disease. …

Aims We aimed to investigate the prevalence and incidence of atrial fibrillation (AF) in a large
European population-based study. Methods and results The study is part of the Rotterdam …