La evidencia científica determina la validez en todas las intervenciones de salud. Estudios
anteriores han demostrado la existencia de evidencia científica favorable en acupuntura. …

Oligodendrocyte death and demyelination are hallmarks of multiple sclerosis (MS). Here we
show that ATP signaling can trigger oligodendrocyte excitotoxicity via activation of calcium-…

Oligodendrocytes make myelin and support axons metabolically with lactate. However, it is
unknown how glucose utilization and glycolysis are adapted to the different axonal energy …

Amyloid beta (Aβ) oligomers accumulate in brain tissue of Alzheimer disease patients and
are related to pathogenesis. The precise mechanisms by which Aβ oligomers cause …

Glutamate kills neurons by excitotoxicity, which is caused by sustained activation of glutamate
receptors. In recent years, it has been shown that glutamate can also be toxic to white …

Fragile X syndrome (FXS), the most common monogenic cause of inherited intellectual disability
and autism 1 , is caused by the silencing of the FMR1 gene, leading to the loss of fragile …

Overactivation of subtype P2X7 receptors can induce excitotoxic neuronal death by calcium
(Ca 2+ ) overload. In this study, we characterize the functional properties of P2X7 receptors …

Phagocytosis is essential to maintain tissue homeostasis in a large number of inflammatory
and autoimmune diseases, but its role in the diseased brain is poorly explored. Recent …

During brain ischemia, an excessive release of glutamate triggers neuronal death through the
overactivation of NMDA receptors (NMDARs); however, the underlying pathways that alter …

Microglia survey the brain microenvironment for signals of injury or infection and are essential
for the initiation and resolution of pathogen‐ or tissue damage‐induced inflammation. …