Mammalian promoters can be separated into two classes, conserved TATA box–enriched
promoters, which initiate at a well-defined site, and more plastic, broad and evolvable CpG-…

Common single-nucleotide polymorphisms (SNPs) are predicted to collectively explain 40–50%
of phenotypic variation in human height, but identifying the specific variants and …

Amyotrophic lateral sclerosis (ALS) is a devastating neurological disease with no effective
treatment. We report the results of a moderate-scale sequencing study aimed at increasing the …

Parkinson's disease (PD), dementia with Lewy bodies and multiple system atrophy, collectively
referred to as synucleinopathies, are associated with a diverse group of genetic and …

To identify novel genes associated with ALS, we undertook two lines of investigation. We
carried out a genome-wide association study comparing 20,806 ALS cases and 59,804 controls…

TDP-43 and FUS are RNA-binding proteins that form cytoplasmic inclusions in some forms
of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). …

A large number of genetic loci are associated with adult body mass index. However, the
genetics of childhood body mass index are largely unknown. We performed a meta-analysis of …

Bone mineral density (BMD) assessed by DXA is used to evaluate bone health. In children,
total body (TB) measurements are commonly used; in older individuals, BMD at the lumbar …

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are overlapping, fatal
neurodegenerative disorders in which the molecular and pathogenic basis remains poorly …

BACKGROUND: Weight-for-length (WFL) is currently used to assess adiposity under 2 years.
We assessed WFL-versus BMI-based estimates of adiposity in healthy infants in …