Background Emerging studies indicate that some coronavirus disease 2019 (COVID-19)
patients suffer from persistent symptoms, including breathlessness and chronic fatigue; however…

The recent revolution in tissue-resident macrophage biology has resulted largely from
murine studies performed in C57BL/6 mice. Here, using both C57BL/6 and BALB/c mice, we …

Inflammatory bowel disease (IBD) pathogenesis is associated with dysregulated CD4 + Th
cell responses, with intestinal homeostasis depending on the balance between IL-17–…

Nippostrongylus brasiliensis is a well-defined model of type-2 immunity but the early lung-migrating
phase is dominated by innate IL-17A production. In this study, we confirm previous …

Background and Purpose— A major process contributing to cell death in the ischemic brain
is inflammation. Inflammasomes are multimolecular protein complexes that drive …

The intestine is a unique immune environment that must respond to infectious organisms
but remain tolerant to commensal microbes and food antigens. However, the molecular …

Innate lymphoid cells (ILCs) are emerging as important regulators of homeostatic and
disease-associated immune processes. Despite recent advances in defining the molecular …

IL-13 is implicated in effective repair after acute lung injury and the pathogenesis of chronic
diseases such as allergic asthma. Both these processes involve matrix remodelling, but …

ALC, RA, AK, AABR, TES, PRG, and JEA designed the research plan. ALC, RA, ZA, JA, JEP,
MMC, BHKC, RME, and PRG performed experiments, analyzed data, and revised the …

The incidence of inflammatory bowel diseases (IBDs) has steadily increased in recent
decades—a phenomenon that cannot be explained by genetic mutations alone. Other factors, …