Cell-fate transitions involve the integration of genomic information encoded by regulatory
elements, such as enhancers, with the cellular environment 1 , 2 . However, identification of …

Protein-binding DNA sequence elements encode a variety of regulated functions of genomes.
Information about such elements is currently in a state of rapid growth, but improved …

Heterozygous mutations in the gene encoding the CHD (chromodomain helicase DNA-binding
domain) member CHD7, an ATP-dependent chromatin remodeller homologous to the …

Neural crest cells (NCC) are a transient, embryonic cell population characterized by
unusual migratory ability and developmental plasticity. To annotate and characterize cis-regulatory …

We report the generation and analysis of functional data from multiple, diverse experiments
performed on a targeted 1% of the human genome as part of the pilot phase of the ENCODE …

The genomes of higher organisms are packaged in nucleosomes with functional histone
modifications. Until now, genome-wide nucleosome and histone modification studies have …

Motivation: Pre-selection of informative features for supervised classification is a crucial,
albeit delicate, task. It is desirable that feature selection provides the features that contribute …

… We thank the Rada-Iglesias lab members for insightful comments and critical reading of the
… Work in the Rada-Iglesias laboratory is supported by CMMC intramural funding, the DFG (…

Prdm14 is a PR-domain and zinc-finger protein whose expression is restricted to the pluripotent
cells of the early embryo, embryonic stem cells (ESCs), and germ cells. Here, we show …

Enhancers play a central role in the spatiotemporal control of gene expression and tend to
work in a cell-type-specific manner. In addition, they are suggested to be major contributors to …