Background Exercise is known to be associated with reduced risk of all-cause mortality,
cardiovascular disease, stroke, and diabetes, but its association with mental health remains …

Objective: Efforts to prevent depression, the leading cause of disability worldwide, have focused
on a limited number of candidate factors. Using phenotypic and genomic data from over …

Objective: Individuals at high risk for schizophrenia may benefit from early intervention, but
few validated risk predictors are available. Genetic profiling is one approach to risk …

Background Physical activity is increasingly recognized as an important modifiable factor for
depression. However, the extent to which individuals with stable risk factors for depression, …

Preeclampsia is a heterogeneous and complex disease associated with rising morbidity and
mortality in pregnant women and newborns in the US. Early recognition of patients at risk is …

Objective: Even though safe and effective treatments for depression are available, many
individuals with a diagnosis of depression do not obtain treatment. This study aimed to develop …

Matt was in many ways the stereotypical “all-American” teenager: a multisport athlete, class
president, and valedictorian of his high school. It seemed preordained that he would attend …

Objective Postpartum hemorrhage (PPH) remains a leading cause of preventable maternal
mortality in the United States. We sought to develop a novel risk assessment tool and …

Importance There is an urgent need to understand patient characteristics of having COVID-19
disease and evaluate markers of critical illness and mortality. Objective To assess …

Recent work suggests that genes encoding complement proteins that are active in the innate
immune system may confer risk for schizophrenia by disrupting typical synaptic pruning in …