Dynamic analysis of redox-based processes in living cells is now restricted by the lack of
appropriate redox biosensors. Conventional redox-sensitive GFPs (roGFPs) are limited by …

Redox biochemistry is increasingly recognized as an integral component of cellular signal
processing and cell fate decision making. Unfortunately, our capabilities to observe and …

The cellular glutathione redox buffer is assumed to be part of signal transduction pathways
transmitting environmental signals during biotic and abiotic stress, and thus is essential for …

H 2 O 2 acts as a signaling molecule by oxidizing critical thiol groups on redox-regulated target
proteins. To explain the efficiency and selectivity of H 2 O 2 -based signaling, it has been …

Formation of reactive oxygen species (ROS) is a common feature of abiotic and biotic stress
reactions. ROS need to be detoxified to avoid deleterious reactions, but at the same time, …

Tight control of cellular redox homeostasis is essential for protection against oxidative
damage and for maintenance of normal metabolism as well as redox signaling events. Under …

Glutathione (GSH) has been implicated in maintaining the cell cycle within plant meristems
and protecting proteins during seed dehydration. To assess the role of GSH during …

Continuous control of metabolism and developmental processes is a key feature of live cells.
Cysteine thiol residues of proteins are both exceptionally useful in terms of structural and …

Significance: Fluorescent protein sensors have revitalized the field of redox biology by
revolutionizing the study of redox processes in living cells and organisms. Recent Advances: …

In Arabidopsis thaliana, biosynthesis of the essential thiol antioxidant, glutathione (GSH), is
plastid-regulated, but many GSH functions, including heavy metal detoxification and plant …