[HTML][HTML] An integrated map of structural variation in 2,504 human genomes
…, B Raeder, EE Schadt, M Romanovitch, A Schlattl… - Nature, 2015 - nature.com
Structural variants are implicated in numerous diseases and make up the majority of varying
nucleotides among human genomes. Here we describe an integrated set of eight structural …
nucleotides among human genomes. Here we describe an integrated set of eight structural …
DELLY: structural variant discovery by integrated paired-end and split-read analysis
Motivation: The discovery of genomic structural variants (SVs) at high sensitivity and
specificity is an essential requirement for characterizing naturally occurring variation and for …
specificity is an essential requirement for characterizing naturally occurring variation and for …
Relating CNVs to transcriptome data at fine resolution: assessment of the effect of variant size, type, and overlap with functional regions
Copy-number variants (CNVs) form an abundant class of genetic variation with a presumed
widespread impact on individual traits. While recent advances, such as the population-scale …
widespread impact on individual traits. While recent advances, such as the population-scale …
Werner syndrome helicase is a selective vulnerability of microsatellite instability-high tumor cells
…, J Rippka, C Schwarz, K Ehrenhöfer-Wölfer, A Schlattl… - Elife, 2019 - elifesciences.org
10.7554/eLife.43333.001 Targeted cancer therapy is based on exploiting selective dependencies
of tumor cells. By leveraging recent functional screening data of cancer cell lines we …
of tumor cells. By leveraging recent functional screening data of cancer cell lines we …
Synthetic lethality between the cohesin subunits STAG1 and STAG2 in diverse cancer contexts
…, J Jude, G Wutz, CP Santos, K Falkenberg, A Schlattl… - Elife, 2017 - elifesciences.org
10.7554/eLife.26980.001 Recent genome analyses have identified recurrent mutations in
the cohesin complex in a wide range of human cancers. Here we demonstrate that the most …
the cohesin complex in a wide range of human cancers. Here we demonstrate that the most …
[PDF][PDF] Interrogation of cancer gene dependencies reveals paralog interactions of autosome and sex chromosome-encoded genes
A Köferle, A Schlattl, A Hörmann, V Thatikonda, A Popa… - Cell reports, 2022 - cell.com
Genetic networks are characterized by extensive buffering. During tumor evolution, disruption
of functional redundancies can create de novo vulnerabilities that are specific to cancer …
of functional redundancies can create de novo vulnerabilities that are specific to cancer …
[HTML][HTML] The baker's yeast diploid genome is remarkably stable in vegetative growth and meiosis
Accurate estimates of mutation rates provide critical information to analyze genome
evolution and organism fitness. We used whole-genome DNA sequencing, pulse-field gel …
evolution and organism fitness. We used whole-genome DNA sequencing, pulse-field gel …
A novel RAF kinase inhibitor with DFG-Out–binding mode: high efficacy in BRAF-mutant tumor xenograft models in the absence of normal tissue hyperproliferation
…, G Bader, O Schaaf, P Garin-Chesa, A Schlattl… - Molecular cancer …, 2016 - AACR
BI 882370 is a highly potent and selective RAF inhibitor that binds to the DFG-out (inactive)
conformation of the BRAF kinase. The compound inhibited proliferation of human BRAF–…
conformation of the BRAF kinase. The compound inhibited proliferation of human BRAF–…
Discovery of potent and selective HER2 inhibitors with efficacy against HER2 exon 20 insertion-driven tumors, which preserve wild-type EGFR signaling
…, D Gerlach, M Bauer, A Bergner, A Schlattl… - Nature Cancer, 2022 - nature.com
Oncogenic alterations in human epidermal growth factor receptor 2 (HER2) occur in
approximately 2% of patients with non-small cell lung cancer and predominantly affect the tyrosine …
approximately 2% of patients with non-small cell lung cancer and predominantly affect the tyrosine …
[HTML][HTML] Systematic inference of copy-number genotypes from personal genome sequencing data reveals extensive olfactory receptor gene content diversity
…, I Keydar, M Khen, AM Stütz, A Schlattl… - PLoS computational …, 2010 - journals.plos.org
Copy-number variations (CNVs) are widespread in the human genome, but comprehensive
assignments of integer locus copy-numbers (ie, copy-number genotypes) that, for example, …
assignments of integer locus copy-numbers (ie, copy-number genotypes) that, for example, …