In recent years experiments have demonstrated that living cells can measure low chemical
concentrations with high precision, and much progress has been made in understanding …

Signal transmission among cells enables long-range coordination in biological systems.
However, the scarcity of quantitative measurements hinders the development of theories that …

Gradient sensing requires at least two measurements at different points in space. These
measurements must then be communicated to a common location to be compared, which is …

Living cells can enhance their fitness by anticipating environmental change. We study how
accurately linear signaling networks in cells can predict future signals. We find that maximal …

Recent single-cell experiments have revived interest in the unavoidable or intrinsic noise in
biochemical and genetic networks arising from the small number of molecules of the …

The past decade has seen great advances in our understanding of the role of noise in gene
regulation and the physical limits to signaling in biological networks. Here, we introduce the …

DNA-based machines that walk by converting chemical energy into controlled motion could
be of use in applications such as next-generation sensors, drug-delivery platforms and …

Collective cell responses to exogenous cues depend on cell–cell interactions. In principle,
these can result in enhanced sensitivity to weak and noisy stimuli. However, this has not yet …

In many cellular signaling pathways, key components form clusters at the cell membrane.
Although much work has focused on the mechanisms behind such cluster formation, the …

Signal-processing molecules inside cells are often present at low copy number, which
necessitates probabilistic models to account for intrinsic noise. Probability distributions have …