User profiles for Artem Babaian
 | Artem Babaian, Ph.D.University of Toronto Verified email at utoronto.ca Cited by 1114 |
[HTML][HTML] Petabase-scale sequence alignment catalyses viral discovery
Public databases contain a planetary collection of nucleic acid sequences, but their systematic
exploration has been inhibited by a lack of efficient methods for searching this corpus, …
exploration has been inhibited by a lack of efficient methods for searching this corpus, …
[HTML][HTML] Hybrids of RNA viruses and viroid-like elements replicate in fungi
Earth’s life may have originated as self-replicating RNA, and it has been argued that RNA
viruses and viroid-like elements are remnants of such pre-cellular RNA world. RNA viruses are …
viruses and viroid-like elements are remnants of such pre-cellular RNA world. RNA viruses are …
[HTML][HTML] Endogenous retroviral promoter exaptation in human cancer
Cancer arises from a series of genetic and epigenetic changes, which result in abnormal
expression or mutational activation of oncogenes, as well as suppression/inactivation of tumor …
expression or mutational activation of oncogenes, as well as suppression/inactivation of tumor …
Length of dsRNA (poly I: C) drives distinct innate immune responses, depending on the cell type
Poly I:C, a synthetic dsRNA analogue, has been used extensively for decades to study innate
responses in vivo and in different cell types. We have found substantial variability while …
responses in vivo and in different cell types. We have found substantial variability while …
[PDF][PDF] Loss of m1acp3Ψ ribosomal RNA modification is a major feature of cancer
The ribosome is an RNA-protein complex that is essential for translation in all domains of life.
The structural and catalytic core of the ribosome is its ribosomal RNA (rRNA). While …
The structural and catalytic core of the ribosome is its ribosomal RNA (rRNA). While …
Distinct isoform of FABP7 revealed by screening for retroelement-activated genes in diffuse large B-cell lymphoma
…, L Gagnier, S Kuah, A Babaian… - Proceedings of the …, 2014 - National Acad Sciences
Remnants of ancient transposable elements (TEs) are abundant in mammalian genomes.
These sequences harbor multiple regulatory motifs and hence are capable of influencing …
These sequences harbor multiple regulatory motifs and hence are capable of influencing …
[HTML][HTML] Ribovirus classification by a polymerase barcode sequence
RNA viruses encoding a polymerase gene (riboviruses) dominate the known eukaryotic
virome. High-throughput sequencing is revealing a wealth of new riboviruses known only from …
virome. High-throughput sequencing is revealing a wealth of new riboviruses known only from …
The miR-185/PAK6 axis predicts therapy response and regulates survival of drug-resistant leukemic stem cells in CML
…, K Rothe, M Chen, A Wu, A Babaian… - Blood, The Journal …, 2020 - ashpublications.org
Overcoming drug resistance and targeting cancer stem cells remain challenges for curative
cancer treatment. To investigate the role of microRNAs (miRNAs) in regulating drug …
cancer treatment. To investigate the role of microRNAs (miRNAs) in regulating drug …
[PDF][PDF] Integrin-linked kinase mediates therapeutic resistance of quiescent CML stem cells to tyrosine kinase inhibitors
Patients with chronic myeloid leukemia (CML) often require lifelong therapy with ABL1 tyrosine
kinase inhibitors (TKIs) due to a persisting TKI-resistant population of leukemic stem cells …
kinase inhibitors (TKIs) due to a persisting TKI-resistant population of leukemic stem cells …
ICTV Virus Taxonomy Profile: Kolmioviridae 2024
Kolmioviridae is a family for negative-sense RNA viruses with circular, viroid-like genomes
of about 1.5–1.7 kb that are maintained in mammals, amphibians, birds, fish, insects and …
of about 1.5–1.7 kb that are maintained in mammals, amphibians, birds, fish, insects and …