What determines whether cells remain in one place, retaining their associations with their
neighbors, or dissociate from these associations and move elsewhere? And, if they move, …

It is widely accepted that the growth and regeneration of tissues and organs is tightly
controlled. Although experimental studies are beginning to reveal molecular mechanisms …

Many patterns of cell and tissue organization are specified during development by gradients
of morphogens, substances that assign different cell fates at different concentrations. …

Systems biology seeks not only to discover the machinery of life but to understand how such
machinery is used for control, ie, for regulation that achieves or maintains a desired, useful …

Cornelia de Lange syndrome (CdLS; OMIM 122470) is a dominantly inherited multisystem
developmental disorder characterized by growth and cognitive retardation; abnormalities of …

Heparan sulfate proteoglycans (HSPGs) play diverse roles in cell recognition, growth, and
adhesion. In vitro studies suggest that cell-surface HSPGs act as coreceptors for heparin-…

Background: Specificity in leukocyte trafficking is likely to depend on sequential interactions
between various cell-type-specific leukocyte adhesion molecules, such as selectins and …

The theory that the spatial organization of cell fate is orchestrated by gradients of diffusing
molecules was a major contribution to 20 th century developmental biology. Although the …

Glypicans are a family of glycosylphosphatidylinositol-anchored cell surface heparan sulfate
proteoglycans implicated in the control of cellular growth and differentiation. Here we show …

Endostatin, a collagen XVIII fragment, is a potent anti-angiogenic protein. We sought to identify
its endothelial cell surface receptor(s). Alkaline phosphatase– tagged endostatin bound …