Autism spectrum disorder (ASD) is a highly heritable and heterogeneous group of
neurodevelopmental phenotypes diagnosed in more than 1% of children. Common genetic variants …

Attention deficit/hyperactivity disorder (ADHD) is a highly heritable childhood behavioral
disorder affecting 5% of children and 2.5% of adults. Common genetic variants contribute …

Bipolar disorder is a highly heritable psychiatric disorder. We performed a genome-wide
association study (GWAS) including 20,352 cases and 31,358 controls of European descent, …

Genetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting
substantial pleiotropy of contributing loci. However, the nature and mechanisms of these …

Pore-forming toxins are critical virulence factors for many bacterial pathogens and are central
to Staphylococcus aureus-mediated killing of host cells. S. aureus encodes pore-forming bi…

Staphylococcus aureus is an important pathogen that continues to be a significant global
health threat because of the prevalence of methicillin‐resistant S. aureus strains (MRSA). The …

Staphylococcus aureus causes diseases ranging from superficial wound infections to more
invasive manifestations like osteomyelitis and endocarditis. The evasion of host phagocytes …

Background Attention-deficit/hyperactivity disorder (ADHD) shows substantial heritability
and is two to seven times more common in male individuals than in female individuals. We …

Methicillin-resistant Staphylococcus aureus (MRSA) strains of the pulsed-field type USA300
are primarily responsible for the current community-associated epidemic of MRSA infections …

Staphylococcus aureus infections are a growing health burden worldwide, and paramount
to this bacterium’s pathogenesis is the production of virulence factors, including pore-forming …