User profiles for Ashok Sivakumar

IK Ashok Sivakumar

Johns Hopkins University
Verified email at jhu.edu
Cited by 4982

Evaluation of machine learning methods to predict peptide binding to MHC Class I proteins

R Bhattacharya, A Sivakumar, C Tokheim, VB Guthrie… - BioRxiv, 2017 - biorxiv.org
Binding of peptides to Major Histocompatibility Complex (MHC) proteins is a critical step in
immune response. Peptides bound to MHCs are recognized by CD8+ (MHC Class I) and CD4…

[PDF][PDF] The immune landscape of cancer

…, JA Eddy, E Ziv, AC Culhane, EO Paull, IKA Sivakumar… - Immunity, 2018 - cell.com
We performed an extensive immunogenomic analysis of more than 10,000 tumors comprising
33 diverse cancer types by utilizing data compiled by TCGA. Across cancer types, we …

[HTML][HTML] Durvalumab with platinum-pemetrexed for unresectable pleural mesothelioma: survival, genomic and immunologic analyses from the phase 2 PrE0505 trial

…, A Balan, JR White, C Cherry, IK Ashok Sivakumar… - Nature medicine, 2021 - nature.com
Mesothelioma is a rare and fatal cancer with limited therapeutic options until the recent approval
of combination immune checkpoint blockade. Here we report the results of the phase 2 …

[HTML][HTML] The immune landscape of cancer

…, JA Eddy, E Ziv, AC Culhane, EO Paull, IKA Sivakumar… - Immunity, 2019 - cell.com
In the originally published version of this article, the authors neglected to include Younes
Mokrab and Aaron M. Newman as co-authors and misspelled the names of authors Charles S. …

Dynamics of tumor and immune responses during immune checkpoint blockade in non–small cell lung cancer

…, C Hruban, J Naidoo, K Marrone, IKA Sivakumar… - Cancer research, 2019 - AACR
… IK Ashok Sivakumar … IK Ashok Sivakumar … White, Noushin Niknafs, Carolyn Hruban,
Jarushka Naidoo, Kristen Marrone, IK Ashok Sivakumar, Daniel C. Bruhm, Samuel Rosner, Jillian …

High-throughput prediction of MHC class I and II neoantigens with MHCnuggets

…, R Bhattacharya, J Huang, IKA Sivakumar… - Cancer immunology …, 2020 - AACR
Computational prediction of binding between neoantigen peptides and major
histocompatibility complex (MHC) proteins can be used to predict patient response to cancer …

[HTML][HTML] Next-generation sequencing of human mitochondrial reference genomes uncovers high heteroplasmy frequency

MX Sosa, IKA Sivakumar, S Maragh… - PLoS computational …, 2012 - journals.plos.org
We describe methods for rapid sequencing of the entire human mitochondrial genome (mtgenome),
which involve long-range PCR for specific amplification of the mtgenome, …

Removal of pharmaceuticals and personal care products during water recycling: microbial community structure and effects of substrate concentration

…, D Berry, JB Proescher, IKA Sivakumar… - Applied and …, 2014 - Am Soc Microbiol
Many pharmaceuticals and personal care products (PPCPs) have been shown to be
biotransformed in water treatment systems. However, little research exists on the effect of initial …

Experimental validation of imposed safety regions for neural controlled human patient self-feeding using the modular prosthetic limb

BA Wester, MP Para, A Sivakumar… - 2013 IEEE/RSJ …, 2013 - ieeexplore.ieee.org
This paper presents the experimental validation of software-based safety features implemented
during the control of a prosthetic limb in self-feeding tasks with a human patient. To …

[PDF][PDF] Stochastic optimization of electricity transmission: dynamic programming algorithms under uncertainties

IKA Sivakumar - 2002 - dspace.mit.edu
This thesis is motivated by the need to optimize transmission capacity as electricity trades
take place in an electric power system. The results obtained use actual data taken from New …