User profiles for Assaad A. Eid
 | Assaad A. EIDAssociate Professor - American University of Beirut, Faculty of Medicine Verified email at aub.edu.lb Cited by 4893 |
[HTML][HTML] COVID-19 and diabetes mellitus: how one pandemic worsens the other
In light of the most challenging public health crisis of modern history, COVID-19 mortality
continues to rise at an alarming rate. Patients with co-morbidities such as hypertension, …
continues to rise at an alarming rate. Patients with co-morbidities such as hypertension, …
[HTML][HTML] Sestrin2 as a novel biomarker and therapeutic target for various diseases
Sestrin2 (SESN2), a highly conserved stress-inducible metabolic protein, is known to repress
reactive oxygen species (ROS) and provide cytoprotection against various noxious stimuli …
reactive oxygen species (ROS) and provide cytoprotection against various noxious stimuli …
[HTML][HTML] NETosis contributes to the pathogenesis of diabetes and its complications
NETosis, a novel form of neutrophil-related cell death, acts as a major regulator of diabetes
and diabetes-associated complications. In this review, we show that the extrusion of …
and diabetes-associated complications. In this review, we show that the extrusion of …
Mechanisms of podocyte injury in diabetes: role of cytochrome P450 and NADPH oxidases
AA Eid, Y Gorin, BM Fagg, R Maalouf, JL Barnes… - Diabetes, 2009 - Am Diabetes Assoc
OBJECTIVE We investigated the role of cytochrome P450 of the 4A family (CYP4A), its
metabolites, and NADPH oxidases both in reactive oxygen species (ROS) production and …
metabolites, and NADPH oxidases both in reactive oxygen species (ROS) production and …
[HTML][HTML] AMP-activated protein kinase (AMPK) negatively regulates Nox4-dependent activation of p53 and epithelial cell apoptosis in diabetes
Diabetes and high glucose (HG) increase the generation of NADPH oxidase-derived reactive
oxygen species and induce apoptosis of glomerular epithelial cells (podocytes). Loss of …
oxygen species and induce apoptosis of glomerular epithelial cells (podocytes). Loss of …
Noninvasive, wearable, and tunable electromagnetic multisensing system for continuous glucose monitoring, mimicking vasculature anatomy
Painless, needle-free, and continuous glucose monitoring sensors are needed to enhance
the life quality of diabetic patients. To that extent, we propose a first-of-its-kind, highly sensitive…
the life quality of diabetic patients. To that extent, we propose a first-of-its-kind, highly sensitive…
Mammalian target of rapamycin regulates Nox4-mediated podocyte depletion in diabetic renal injury
Podocyte apoptosis is a critical mechanism for excessive loss of urinary albumin that eventuates
in kidney fibrosis. Pharmacological doses of the mammalian target of rapamycin (mTOR…
in kidney fibrosis. Pharmacological doses of the mammalian target of rapamycin (mTOR…
[HTML][HTML] Nox4 NADPH oxidase mediates peroxynitrite-dependent uncoupling of endothelial nitric-oxide synthase and fibronectin expression in response to …
DY Lee, F Wauquier, AA Eid, LJ Roman… - Journal of Biological …, 2013 - ASBMB
Background: Oxidative stress is critical for the fibrotic response of mesangial cells (MCs) to
angiotensin II. Results: Nox4- and mitochondrial reactive oxygen species (ROS)-dependent …
angiotensin II. Results: Nox4- and mitochondrial reactive oxygen species (ROS)-dependent …
Sestrin 2 and AMPK connect hyperglycemia to Nox4-dependent endothelial nitric oxide synthase uncoupling and matrix protein expression
AA Eid, DY Lee, LJ Roman, K Khazim… - Molecular and cellular …, 2013 - Taylor & Francis
Mesangial matrix accumulation is an early feature of glomerular pathology in diabetes.
Oxidative stress plays a critical role in hyperglycemia-induced glomerular injury. Here, we …
Oxidative stress plays a critical role in hyperglycemia-induced glomerular injury. Here, we …
Nox4-derived reactive oxygen species mediate cardiomyocyte injury in early type 1 diabetes
RM Maalouf, AA Eid, YC Gorin… - … of Physiology-Cell …, 2012 - journals.physiology.org
Oxidative stress contributes to diabetic cardiomyopathy. This study explored the role of the
NADPH oxidase Nox4 as a source of reactive oxygen species (ROS) involved in the …
NADPH oxidase Nox4 as a source of reactive oxygen species (ROS) involved in the …