Piezoresistive sensors are among the earliest micromachined silicon devices. The need for
smaller, less expensive, higher performance sensors helped drive early micromachining …

Classical cadherins are transmembrane proteins at the core of intercellular adhesion
complexes in cohesive metazoan tissues. The extracellular domain of classical cadherins forms …

Mechanical strain regulates the development, organization, and function of multicellular
tissues, but mechanisms linking mechanical strain and cell-cell junction proteins to cellular …

Single cardiomyocytes contain myofibrils that harbor the sarcomere-based contractile
machinery of the myocardium. Cardiomyocytes differentiated from human pluripotent stem cells (…

Adjusting the acrylamide monomer and cross-linker content in polyacrylamide gels controls
the hydrogel stiffness, yet the reported elastic modulus for the same formulations varies …

Mechanotransduction - how cells sense physical forces and translate them into biochemical
and biological responses - is a vibrant and rapidly-progressing field, and is important for a …

Mutation of highly conserved residues in transcription factors may affect protein-protein or
protein-DNA interactions, leading to gene network dysregulation and human disease. Human …

Human pluripotent stem cell (hPSC-) derived cardiomyocytes have potential applications in
drug discovery, toxicity testing, developmental studies, and regenerative medicine. Before …

With a nervous system of only 302 neurons, the free-living nematode Caenorhabditis elegans
is a powerful experimental organism for neurobiology. However, the laboratory substrate …

Studying animal mechanics is critical for understanding how signals in the neuromuscular
system give rise to behavior and how force-sensing organs and sensory neurons work. Few …