Coffee, a major dietary source of caffeine, is among the most widely consumed beverages in
the world and has received considerable attention regarding health risks and benefits. We …

Obesity is heritable and predisposes to many diseases. To understand the genetic basis of
obesity better, here we conduct a genome-wide association study and Metabochip meta-…

Using genome-wide data from 253,288 individuals, we identified 697 variants at genome-wide
significance that together explained one-fifth of the heritability for adult height. By testing …

We estimate and partition genetic variation for height, body mass index (BMI), von
Willebrand factor and QT interval (QTi) using 586,898 SNPs genotyped on 11,586 unrelated …

We detected clonal mosaicism for large chromosomal anomalies (duplications, deletions
and uniparental disomy) using SNP microarray data from over 50,000 subjects recruited for …

To identify loci for age at menarche, we performed a meta-analysis of 32 genome-wide
association studies in 87,802 women of European descent, with replication in up to 14,731 …

Age at menarche is a marker of timing of puberty in females. It varies widely between
individuals, is a heritable trait and is associated with risks for obesity, type 2 diabetes, …

Genetic association studies have identified 21 loci associated with atopic dermatitis risk
predominantly in populations of European ancestry. To identify further susceptibility loci for this …

Although physical activity and sedentary behavior are moderately heritable, little is known
about the mechanisms that influence these traits. Combining data for up to 703,901 …

We examined common variation in asthma risk by conducting a meta-analysis of worldwide
asthma genome-wide association studies (23,948 asthma cases, 118,538 controls) of …