Primitive neuroectodermal tumors of the central nervous system (CNS-PNETs) are highly
aggressive, poorly differentiated embryonal tumors occurring predominantly in young children …

cIMPACT‐NOW (the Consortium to Inform Molecular and Practical Approaches to CNS Tumor
Taxonomy) was established to evaluate and make practical recommendations on recent …

Purpose Two phase II studies assessed the efficacy of vismodegib, a sonic hedgehog (SHH)
pathway inhibitor that binds smoothened (SMO), in pediatric and adult recurrent …

Medulloblastoma is a highly malignant paediatric brain tumour, often inflicting devastating
consequences on the developing child. Genomic studies have revealed four distinct …

Medulloblastoma is a malignant childhood cerebellar tumour type that comprises distinct
molecular subgroups. Whereas genomic characteristics of these subgroups are well defined, …

Cancers comprise a heterogeneous group of human diseases. Unifying characteristics
include unchecked abilities of tumor cells to proliferate and spread anatomically, and the …

Pediatric cancers are driven by diverse genomic lesions, and sequencing has proven useful
in evaluating high-risk and relapsed/refractory cases. We show that combined WGS, WES, …

Here we show that activation of the canonical WNT/β-catenin pathway increases the expression
of stem cell genes and promotes the migratory and invasive capacity of glioblastoma. …

Medulloblastoma, a malignant childhood cerebellar tumour, segregates molecularly into
biologically distinct subgroups, suggesting that a personalized approach to therapy would be …

Epigenetic modification of DNA by cytosine methylation to produce 5-methylcytosine (5mC)
has become well-recognized as an important epigenetic process in human health and …