The mammalian nervous system comprises many distinct neuronal subtypes, each with its
own phenotype and differential sensitivity to degenerative disease. Although specific …

Amyotrophic lateral sclerosis (ALS) is a rapidly progressing neurodegenerative disease,
characterized by motor neuron (MN) death, for which there are no truly effective treatments. Here…

Alzheimer’s disease is the most common form of dementia, characterized by two pathological
hallmarks: amyloid-β plaques and neurofibrillary tangles 1 . The amyloid hypothesis of …

Human induced pluripotent stem cells (iPSCs) present exciting opportunities for studying
development and for in vitro disease modeling. However, reported variability in the behavior of …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease of the motor
nervous system. We show using multielectrode array and patch-clamp recordings that …

The findings that amyotrophic lateral sclerosis (ALS) patients almost universally display
pathological mislocalization of the RNA-binding protein TDP-43 and that mutations in its gene …

Importance Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease
of the motor nervous system. Clinical studies have demonstrated cortical and spinal motor …

Hyperpolarization-activated cation channels of the HCN gene family 1 , 2 , 3 , 4 , 5 , 6
contribute to spontaneous rhythmic activity in both heart 7 and brain 5 , 6 , 8 . All four family …

Although many distinct mutations in a variety of genes are known to cause Amyotrophic Lateral
Sclerosis (ALS), it remains poorly understood how they selectively impact motor neuron …

Reprogramming somatic cells from one cell fate to another can generate specific neurons
suitable for disease modeling. To maximize the utility of patient-derived neurons, they must …