Fibrosis is a process characterized by an excessive accumulation of the extracellular matrix
as a response to different types of tissue injuries, which leads to organ dysfunction. The …

The key players of the chronic kidney disease-mineral and bone disorders (CKD-MBD) are
calcium, phosphate, PTH, FGF23, and the vitamin D hormonal system. The progressive …

Bone loss and increased fractures are common complications in chronic kidney disease.
Because Wnt pathway activation is essential for normal bone mineralization, we assessed …

… The blood was collected in tubes with or without EDTA and centrifuged at 3000 rpm for 15
min at 4 C to obtain plasma or serum, respectively, and stored at −80 C until analysis. The …

Background In chronic kidney disease (CKD), increases in serum phosphate and parathyroid
hormone (PTH) aggravate vascular calcification (VC) and bone loss. This study was …

Background In chronic kidney disease, the activation of the renin–angiotensin–aldosterone
system (RAAS) and renal inflammation stimulates renal fibrosis and the progression to end-…

Preclinical biomedical models are a fundamental tool to improve the knowledge and
management of diseases, particularly in diabetes mellitus (DM) since, currently, the …

This study was designed to investigate the controversy on the potential role of sKlotho as an
early biomarker in Chronic Kidney Disease–Mineral Bone Disorder (CKD-MBD), to assess …

… Forty cycles at 95 C for 17 s and 60 C for 1 minute were performed. Duplicate readings
were … at 37 C. The supernatant was collected and centrifuged for 10 minutes at 1100g, at 4 …

Early ocular disease diagnosis is an important field in medical research. From the image
processing point of view, many strategies and algorithms have been developed to deal with the …