The effect of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on
the pathophysiology of the placenta and its impact on pregnancy outcome has not yet been …

Identifying molecular cancer drivers is critical for precision oncology. Multiple advanced
algorithms to identify drivers now exist, but systematic attempts to combine and optimize them on …

Chronic lymphocytic leukaemia (CLL) is a frequent disease in which the genetic alterations
determining the clinicobiological behaviour are not fully understood. Here we describe a …

While tumor genome sequencing has become widely available in clinical and research
settings, the interpretation of tumor somatic variants remains an important bottleneck. Here we …

Large efforts dedicated to detect somatic alterations across tumor genomes/exomes are
expected to produce significant improvements in precision cancer medicine. However, high inter-…

Tyrosine kinase inhibitors were found to be clinically effective for treatment of patients with
certain subsets of cancers carrying somatic mutations in receptor tyrosine kinases. However, …

Purpose: Throughout their development, tumors are challenged by the immune system, and
they acquire features to evade its surveillance. A systematic view of these traits, which shed …

Cancer response to immunotherapy depends on the infiltration of CD8 + T cells and the
presence of tumor-associated macrophages within tumors. Still, little is known about the …

The tumor immune microenvironment is a main contributor to cancer progression and a
promising therapeutic target for oncology. However, immune microenvironments vary profoundly …

The molecular characterisation of medulloblastoma, the most common paediatric brain
tumour, is crucial for the correct management and treatment of this heterogenous disease. …