The cohesin complex is a major constituent of interphase and mitotic chromosomes. Apart
from its role in mediating sister chromatid cohesion, it is also important for DNA double-strand-…

Imaging and chromosome conformation capture studies have revealed several layers of
chromosome organization, including segregation into megabase-sized active and inactive …

Sister chromatids are held together by the multisubunit cohesin complex, which contains two
SMC (Smc1 and Smc3) and two non-SMC (Scc1 and Scc3) proteins. The crystal structure of …

The cohesin complex is essential for sister chromatid cohesion during mitosis. Its Smc1 and
Smc3 subunits are rod-shaped molecules with globular ABC-like ATPases at one end and …

▪ Abstract Protein complexes consisting of structural maintenance of chromosomes (SMC)
and kleisin subunits are crucial for the faithful segregation of chromosomes during cell …

It has been hypothesized that SMC protein complexes such as condensin and cohesin
spatially organize chromosomes by extruding DNA into large loops. We directly visualized the …

Sister chromatid cohesion, which is essential for mitosis, is mediated by a multi-subunit protein
complex called cohesin. Cohesin’s Scc1, Smc1 and Smc3 subunits form a tripartite ring …

A multisubunit complex called cohesin forms a huge ring structure that mediates sister
chromatid cohesion, possibly by entrapping sister DNAs following replication. Cohesin's kleisin …

Background: A multi-subunit protein complex called cohesin is involved in holding sister
chromatids together after DNA replication. Cohesin contains four core subunits: Smc1, Smc3, …

Cohesion between sister chromatids is established during S phase and maintained through
G2 phase until it is resolved in anaphase (for review, see [1–3]). In Saccharomyces …