Defects in the structure or function of the primary cilium, an antennae-like structure whose
functional integrity has been linked to the suppression of uncontrolled kidney epithelial cell …

Control of cell proliferation is a fundamental aspect of tissue formation in development and
regeneration. Cells experience various spatial and mechanical constraints depending on …

Expansion of a single repetitive DNA sequence, termed a tandem repeat (TR), is known to
cause more than 50 diseases 1 , 2 . However, repeat expansions are often not explored …

An important hallmark of cancer is ‘metabolic reprogramming’or the rewiring of cellular
metabolism to support rapid cell proliferation [1–5]. Metabolic reprogramming through …

10.7554/eLife.29061.001 Centrioles are composed of long-lived microtubules arranged in
nine triplets. However, the contribution of triplet microtubules to mammalian centriole …

Von Hippel-Lindau (VHL) tumor suppressor gene mutations predispose carriers to kidney
cancer. The protein pVHL has been shown to interact with microtubules (MTs), which is critical …

With 15 drugs currently approved for the treatment of metastatic renal cell carcinoma (mRCC)
and even more combination regimens with immunotherapy on the horizon, there remains a …

Alterations in cellular sugar, amino acid and nucleic acid, and lipid metabolism, as well as
in mitochondrial function, are a hallmark of renal cell carcinoma (RCC). The activation of …

Therapies for metastatic castration-resistant prostate cancer (mCRPC) include targeting the
androgen receptor (AR) with androgen receptor inhibitors (ARIs) and prostate-specific …

Magnetic levitation‐based sorting technologies have revolutionized the detection and isolation
of rare cells, including circulating tumor cells (CTCs) and circulating tumor cell clusters (…