The CD200–CD200R1 inhibitory signaling pathway: immune regulation and host–pathogen interactions
CA Vaine, RJ Soberman - Advances in immunology, 2014 - Elsevier
The CD200:CD200R1 inhibitory signaling pathway has been implicated in playing a
prominent role in limiting inflammation in a wide range of inflammatory diseases. CD200R1 …
prominent role in limiting inflammation in a wide range of inflammatory diseases. CD200R1 …
[PDF][PDF] Dissecting the causal mechanism of X-linked dystonia-parkinsonism by integrating genome and transcriptome assembly
X-linked Dystonia-Parkinsonism (XDP) is a Mendelian neurodegenerative disease that is
endemic to the Philippines and is associated with a founder haplotype. We integrated multiple …
endemic to the Philippines and is associated with a founder haplotype. We integrated multiple …
Disease onset in X-linked dystonia-parkinsonism correlates with expansion of a hexameric repeat within an SVA retrotransposon in TAF1
…, K Mangkalaphiban, CA Vaine… - Proceedings of the …, 2017 - National Acad Sciences
X-linked dystonia-parkinsonism (XDP) is a neurodegenerative disease associated with an
antisense insertion of a SINE-VNTR-Alu (SVA)-type retrotransposon within an intron of TAF1. …
antisense insertion of a SINE-VNTR-Alu (SVA)-type retrotransposon within an intron of TAF1. …
Tuning innate immune activation by surface texturing of polymer microparticles: the role of shape in inflammasome activation
CA Vaine, MK Patel, J Zhu, E Lee… - The Journal of …, 2013 - journals.aai.org
Polymeric microparticles have been widely investigated as platforms for delivery of drugs,
vaccines, and imaging contrast agents and are increasingly used in a variety of clinical …
vaccines, and imaging contrast agents and are increasingly used in a variety of clinical …
Decreased N-TAF1 expression in X-linked dystonia-parkinsonism patient-specific neural stem cells
…, WT Hendriks, J Dhakal, CA Vaine… - Disease models & …, 2016 - journals.biologists.com
X-linked dystonia-parkinsonism (XDP) is a hereditary neurodegenerative disorder involving
a progressive loss of striatal medium spiny neurons. The mechanisms underlying …
a progressive loss of striatal medium spiny neurons. The mechanisms underlying …
[HTML][HTML] Neuroinflammation and histone H3 citrullination are increased in X-linked Dystonia Parkinsonism post-mortem prefrontal cortex
T Petrozziello, AN Mills, CA Vaine, EB Penney… - Neurobiology of …, 2020 - Elsevier
Neuroinflammation plays a pathogenic role in neurodegenerative diseases and recent
findings suggest that it may also be involved in X-linked Dystonia-Parkinsonism (XDP) …
findings suggest that it may also be involved in X-linked Dystonia-Parkinsonism (XDP) …
TAF1 Transcripts and Neurofilament Light Chain as Biomarkers for X‐linked Dystonia‐Parkinsonism
J Al Ali, CA Vaine, S Shah, L Campion… - Movement …, 2021 - Wiley Online Library
Background X‐linked dystonia‐parkinsonism is a rare neurological disease endemic to the
Philippines. Dystonic symptoms appear in males at the mean age of 40 years and progress …
Philippines. Dystonic symptoms appear in males at the mean age of 40 years and progress …
The nuclear membrane leukotriene synthetic complex is a signal integrator and transducer
AM Bair, MV Turman, CA Vaine… - Molecular biology of …, 2012 - Am Soc Cell Biol
Leukotrienes (LTs) are lipid-signaling molecules derived from arachidonic acid (AA) that
initiate and amplify inflammation. To initiate LT formation, the 5-lipoxygenase (5-LO) enzyme …
initiate and amplify inflammation. To initiate LT formation, the 5-lipoxygenase (5-LO) enzyme …
[HTML][HTML] CD200R1 supports HSV-1 viral replication and licenses pro-inflammatory signaling functions of TLR2
RJ Soberman, CR MacKay, CA Vaine, GB Ryan… - 2012 - journals.plos.org
The CD200R1:CD200 axis is traditionally considered to limit tissue inflammation by down-regulating
pro-inflammatory signaling in myeloid cells bearing the receptor. We generated …
pro-inflammatory signaling in myeloid cells bearing the receptor. We generated …
[HTML][HTML] SVA insertion in X-linked Dystonia Parkinsonism alters histone H3 acetylation associated with TAF1 gene
T Petrozziello, AM Dios, KA Mueller, CA Vaine… - PLoS …, 2020 - journals.plos.org
X-linked Dystonia-Parkinsonism (XDP) is a neurodegenerative disease linked to an
insertion of a SINE-VNTR-Alu (SVA)-type retrotransposon within an intron of TAF1. This SVA …
insertion of a SINE-VNTR-Alu (SVA)-type retrotransposon within an intron of TAF1. This SVA …