We generated genome-wide data from 69 Europeans who lived between 8,000–3,000 years
ago by enriching ancient DNA libraries for a target set of almost 400,000 polymorphisms. …

We sequenced the genomes of a ∼7,000-year-old farmer from Germany and eight ∼8,000-year-old
hunter-gatherers from Luxembourg and Sweden. We analysed these and other …

Leprosy was endemic in Europe until the Middle Ages. Using DNA array capture, we have
obtained genome sequences of Mycobacterium leprae from skeletons of five medieval …

While the series of events that shaped the transition between foraging societies and food
producers are well described for Central and Southern Europe, genetic evidence from Northern …

Background During the past decades Streptococcus pneumoniae has developed significant
resistance to many classes of antimicrobial drugs. Potential risk factors for colonization of …

Alkaloids, secondary metabolites that contain basic nitrogen atoms, are some of the most
well-known biologically active natural products in chemistry and medicine 1 . Although efficient …

Leprosy is a chronic infection of the skin and peripheral nerves caused by the pathogen
Mycobacterium leprae. Its impact on human populations and societies of the past as well as its …

There is plenty of proof that environmental noise is a major pollutant in the urban environment.
Several approaches were successfully applied for its calculation, visualization, prediction …

The antiproliferative antimicrobial fungal metabolites known as the myrocins have been
proposed to cross-link DNA by double nucleotide addition. However, the nature of the DNA-…

We recently reported a convergent strategy to access the polycyclic guanidinium alkaloid (+)-batzelladine
B via an aldol addition–retro-aldol–aza-Michael addition cascade. Here we …