Dendritic cells can prime naive CD4 + T cells; however, here we demonstrate that dendritic
cell–mediated priming was insufficient for the development of T helper type 2 cell–dependent …

Intestinal epithelial cells (IECs) provide a primary physical barrier against commensal and
pathogenic microorganisms in the gastrointestinal (GI) tract, but the influence of IECs on the …

IL-22 has both proinflammatory and tissue-protective properties depending on the context in
which it is expressed. However, the factors that influence the functional outcomes of IL-22 …

The cytokine interleukin (IL) 25 has been implicated in the initiation of type 2 immunity by
driving the expression of type 2 cytokines such as IL-5 and IL-13, although its role in the …

Intestinal epithelial cells (IECs) produce thymic stromal lymphopoietin (TSLP); however, the
in vivo influence of TSLP–TSLP receptor (TSLPR) interactions on immunity and inflammation …

Infection with Leishmania major induces a protective immune response and long-term
resistance to reinfection, which is thought to depend upon persistent parasites. Here we …

Differentiation and recruitment of alternatively activated macrophages (AAMacs) are hallmarks
of several inflammatory conditions associated with infection, allergy, diabetes, and cancer…

Alterations in the composition of intestinal commensal bacteria are associated with enhanced
susceptibility to multiple inflammatory diseases, including those conditions associated with …

Background Allergic inflammation involves the sensitization of naive CD4 + T cells to allergens,
resulting in a T H 2-skewed inflammatory response. Although antigen presentation by …

SET domain containing (lysine methyltransferase) 7 (SETD7) is implicated in multiple
signaling and disease related pathways with a broad diversity of reported substrates. Here, we …