User profiles for Dadi Gao
 | Dadi GaoHarvard Medical School Verified email at mgh.harvard.edu Cited by 2227 |
[HTML][HTML] Orchestrated intron retention regulates normal granulocyte differentiation
Intron retention (IR) is widely recognized as a consequence of mis-splicing that leads to failed
excision of intronic sequences from pre-messenger RNAs. Our bioinformatic analyses of …
excision of intronic sequences from pre-messenger RNAs. Our bioinformatic analyses of …
Targeting ASCT2‐mediated glutamine uptake blocks prostate cancer growth and tumour development
Glutamine is conditionally essential in cancer cells, being utilized as a carbon and nitrogen
source for macromolecule production, as well as for anaplerotic reactions fuelling the …
source for macromolecule production, as well as for anaplerotic reactions fuelling the …
[HTML][HTML] IRFinder: assessing the impact of intron retention on mammalian gene expression
Intron retention (IR) occurs when an intron is transcribed into pre-mRNA and remains in the
final mRNA. We have developed a program and database called IRFinder to accurately …
final mRNA. We have developed a program and database called IRFinder to accurately …
[PDF][PDF] Dissecting the causal mechanism of X-linked dystonia-parkinsonism by integrating genome and transcriptome assembly
X-linked Dystonia-Parkinsonism (XDP) is a Mendelian neurodegenerative disease that is
endemic to the Philippines and is associated with a founder haplotype. We integrated multiple …
endemic to the Philippines and is associated with a founder haplotype. We integrated multiple …
[HTML][HTML] Intron retention is regulated by altered MeCP2-mediated splicing factor recruitment
While intron retention (IR) is considered a widely conserved and distinct mechanism of gene
expression control, its regulation is poorly understood. Here we show that DNA methylation …
expression control, its regulation is poorly understood. Here we show that DNA methylation …
[HTML][HTML] A deep learning approach to identify gene targets of a therapeutic for human splicing disorders
Pre-mRNA splicing is a key controller of human gene expression. Disturbances in splicing
due to mutation lead to dysregulated protein expression and contribute to a substantial …
due to mutation lead to dysregulated protein expression and contribute to a substantial …
[PDF][PDF] Tissue-and cell-type-specific molecular and functional signatures of 16p11. 2 reciprocal genomic disorder across mouse brain and human neuronal models
Chromosome 16p11.2 reciprocal genomic disorder, resulting from recurrent copy-number
variants (CNVs), involves intellectual disability, autism spectrum disorder (ASD), and …
variants (CNVs), involves intellectual disability, autism spectrum disorder (ASD), and …
RBM3 regulates temperature sensitive miR-142–5p and miR-143 (thermomiRs), which target immune genes and control fever
Fever is commonly used to diagnose disease and is consistently associated with increased
mortality in critically ill patients. However, the molecular controls of elevated body …
mortality in critically ill patients. However, the molecular controls of elevated body …
[PDF][PDF] ELP1 splicing correction reverses proprioceptive sensory loss in familial dysautonomia
Familial dysautonomia (FD) is a recessive neurodegenerative disease caused by a splice
mutation in Elongator complex protein 1 (ELP1, also known as IKBKAP); this mutation leads to …
mutation in Elongator complex protein 1 (ELP1, also known as IKBKAP); this mutation leads to …
miREval 2.0: a web tool for simple microRNA prediction in genome sequences
Result: We have developed miREval 2.0, an online tool that can simultaneously search up
to 100 sequences for novel microRNAs (miRNAs) in multiple organisms. miREval 2.0 uses …
to 100 sequences for novel microRNAs (miRNAs) in multiple organisms. miREval 2.0 uses …