User profiles for Damiano Fantini
 | Damiano FantiniNorthwestern University Verified email at northwestern.edu Cited by 1644 |
[HTML][HTML] A Carcinogen-induced mouse model recapitulates the molecular alterations of human muscle invasive bladder cancer
The N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN) mouse model is an attractive model
system of muscle-invasive bladder cancer (MIBC) as it recapitulates the histology of human …
system of muscle-invasive bladder cancer (MIBC) as it recapitulates the histology of human …
[HTML][HTML] MutSignatures: an R package for extraction and analysis of cancer mutational signatures
Cancer cells accumulate somatic mutations as result of DNA damage, inaccurate repair and
other mechanisms. Different genetic instability processes result in characteristic non-…
other mechanisms. Different genetic instability processes result in characteristic non-…
Resetting the epigenetic balance of Polycomb and COMPASS function at enhancers for cancer therapy
The lysine methyltransferase KMT2C (also known as MLL3), a subunit of the COMPASS
complex, implements monomethylation of Lys4 on histone H3 (H3K4) at gene enhancers. …
complex, implements monomethylation of Lys4 on histone H3 (H3K4) at gene enhancers. …
Identification of differential tumor subtypes of T1 bladder cancer
Stage T1 bladder cancers have the highest progression and recurrence rates of all non–muscle-invasive
bladder cancers (NMIBCs). Most T1 cancers are treated with bacillus Calmette-…
bladder cancers (NMIBCs). Most T1 cancers are treated with bacillus Calmette-…
Antibody targeting of B7-H4 enhances the immune response in urothelial carcinoma
Patients with locally advanced and metastatic urothelial carcinoma have a low survival rate (median
15.7 months, 13.1–17.8), with only a 23% response rate to monotherapy treatment …
15.7 months, 13.1–17.8), with only a 23% response rate to monotherapy treatment …
Immune activation is essential for the antitumor activity of EZH2 inhibition in urothelial carcinoma
…, JR Podojil, KA McLaughlin, Z You, D Fantini… - Science …, 2022 - science.org
The long-term survival of patients with advanced urothelial carcinoma (UCa) is limited
because of innate resistance to treatment. We identified elevated expression of the histone …
because of innate resistance to treatment. We identified elevated expression of the histone …
APE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in the rRNA quality control process
C Vascotto, D Fantini, M Romanello… - … and cellular biology, 2009 - Am Soc Microbiol
APE1/Ref-1 (hereafter, APE1), a DNA repair enzyme and a transcriptional coactivator, is a
vital protein in mammals. Its role in controlling cell growth and the molecular mechanisms that …
vital protein in mammals. Its role in controlling cell growth and the molecular mechanisms that …
Understanding different functions of mammalian AP endonuclease (APE1) as a promising tool for cancer treatment
The apurinic endonuclease 1/redox factor-1 (APE1) has a crucial function in DNA repair
and in redox signaling in mammals, and recent studies identify it as an excellent target for …
and in redox signaling in mammals, and recent studies identify it as an excellent target for …
The evolving genomic landscape of urothelial carcinoma
Survival of patients with urothelial carcinoma (including bladder cancer and upper tract
urothelial carcinoma) is limited by our current approaches to staging, surgery, and chemotherapy…
urothelial carcinoma) is limited by our current approaches to staging, surgery, and chemotherapy…
Critical lysine residues within the overlooked N-terminal domain of human APE1 regulate its biological functions
Apurinic/apyrimidinic endonuclease 1 (APE1), an essential protein in mammals, is involved
in base excision DNA repair (BER) and in regulation of gene expression, acting as a redox …
in base excision DNA repair (BER) and in regulation of gene expression, acting as a redox …