User profiles for Daniel Geschwind
Dan GeschwindDistinguished Professor of Neurology, Psychiatry and Human Genetics, UCLA Verified email at mednet.ucla.edu Cited by 148795 |
Identification of common genetic risk variants for autism spectrum disorder
…, BUPGEN, K Stefansson, DH Geschwind… - Nature …, 2019 - nature.com
Autism spectrum disorder (ASD) is a highly heritable and heterogeneous group of
neurodevelopmental phenotypes diagnosed in more than 1% of children. Common genetic variants …
neurodevelopmental phenotypes diagnosed in more than 1% of children. Common genetic variants …
Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder
Attention deficit/hyperactivity disorder (ADHD) is a highly heritable childhood behavioral
disorder affecting 5% of children and 2.5% of adults. Common genetic variants contribute …
disorder affecting 5% of children and 2.5% of adults. Common genetic variants contribute …
Advances in autism genetics: on the threshold of a new neurobiology
BS Abrahams, DH Geschwind - Nature reviews genetics, 2008 - nature.com
Autism is a heterogeneous syndrome defined by impairments in three core domains: social
interaction, language and range of interests. Recent work has led to the identification of …
interaction, language and range of interests. Recent work has led to the identification of …
[PDF][PDF] Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS
…, WW Seeley, KA Josephs, G Coppola, DH Geschwind… - Neuron, 2011 - cell.com
Several families have been reported with autosomal-dominant frontotemporal dementia (FTD)
and amyotrophic lateral sclerosis (ALS), genetically linked to chromosome 9p21. Here, we …
and amyotrophic lateral sclerosis (ALS), genetically linked to chromosome 9p21. Here, we …
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease
…, DR Galasko, M Ganguli, M Gearing, DH Geschwind… - Nature …, 2011 - nature.com
The Alzheimer Disease Genetics Consortium (ADGC) performed a genome-wide association
study of late-onset Alzheimer disease using a three-stage design consisting of a discovery …
study of late-onset Alzheimer disease using a three-stage design consisting of a discovery …
An anatomically comprehensive atlas of the adult human brain transcriptome
…, D Williams, P Wohnoutka, HR Zielke, DH Geschwind… - Nature, 2012 - nature.com
Neuroanatomically precise, genome-wide maps of transcript distributions are critical resources
to complement genomic sequence data and to correlate functional and genetic brain …
to complement genomic sequence data and to correlate functional and genetic brain …
[PDF][PDF] Multiple recurrent de novo CNVs, including duplications of the 7q11. 23 Williams syndrome region, are strongly associated with autism
…, AI Brooks, JS Sutcliffe, EH Cook, D Geschwind… - Neuron, 2011 - cell.com
We have undertaken a genome-wide analysis of rare copy-number variation (CNV) in 1124
autism spectrum disorder (ASD) families, each comprised of a single proband, unaffected …
autism spectrum disorder (ASD) families, each comprised of a single proband, unaffected …
Transcriptomic analysis of autistic brain reveals convergent molecular pathology
Autism spectrum disorder (ASD) is a common, highly heritable neurodevelopmental condition
characterized by marked genetic heterogeneity 1 , 2 , 3 . Thus, a fundamental question is …
characterized by marked genetic heterogeneity 1 , 2 , 3 . Thus, a fundamental question is …
Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap
…, S Horvath, DH Geschwind - Science, 2018 - science.org
The predisposition to neuropsychiatric disease involves a complex, polygenic, and pleiotropic
genetic architecture. However, little is known about how genetic variants impart brain …
genetic architecture. However, little is known about how genetic variants impart brain …
Dentate granule cell neurogenesis is increased by seizures and contributes to aberrant network reorganization in the adult rat hippocampus
…, WY Timothy, RT Leibowitz, DH Geschwind… - Journal of …, 1997 - Soc Neuroscience
The dentate granule cell layer of the rodent hippocampal formation has the distinctive property
of ongoing neurogenesis that continues throughout adult life. In both human temporal …
of ongoing neurogenesis that continues throughout adult life. In both human temporal …