User profiles for Daniel Geschwind

Dan Geschwind

Distinguished Professor of Neurology, Psychiatry and Human Genetics, UCLA
Verified email at mednet.ucla.edu
Cited by 148795

Identification of common genetic risk variants for autism spectrum disorder

…, BUPGEN, K Stefansson, DH Geschwind… - Nature …, 2019 - nature.com
Autism spectrum disorder (ASD) is a highly heritable and heterogeneous group of
neurodevelopmental phenotypes diagnosed in more than 1% of children. Common genetic variants …

Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder

…, S Dalsgaard, B Franke, J Gelernter, D Geschwind… - Nature …, 2019 - nature.com
Attention deficit/hyperactivity disorder (ADHD) is a highly heritable childhood behavioral
disorder affecting 5% of children and 2.5% of adults. Common genetic variants contribute …

Advances in autism genetics: on the threshold of a new neurobiology

BS Abrahams, DH Geschwind - Nature reviews genetics, 2008 - nature.com
Autism is a heterogeneous syndrome defined by impairments in three core domains: social
interaction, language and range of interests. Recent work has led to the identification of …

[PDF][PDF] Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS

…, WW Seeley, KA Josephs, G Coppola, DH Geschwind… - Neuron, 2011 - cell.com
Several families have been reported with autosomal-dominant frontotemporal dementia (FTD)
and amyotrophic lateral sclerosis (ALS), genetically linked to chromosome 9p21. Here, we …

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease

…, DR Galasko, M Ganguli, M Gearing, DH Geschwind… - Nature …, 2011 - nature.com
The Alzheimer Disease Genetics Consortium (ADGC) performed a genome-wide association
study of late-onset Alzheimer disease using a three-stage design consisting of a discovery …

An anatomically comprehensive atlas of the adult human brain transcriptome

…, D Williams, P Wohnoutka, HR Zielke, DH Geschwind… - Nature, 2012 - nature.com
Neuroanatomically precise, genome-wide maps of transcript distributions are critical resources
to complement genomic sequence data and to correlate functional and genetic brain …

[PDF][PDF] Multiple recurrent de novo CNVs, including duplications of the 7q11. 23 Williams syndrome region, are strongly associated with autism

…, AI Brooks, JS Sutcliffe, EH Cook, D Geschwind… - Neuron, 2011 - cell.com
We have undertaken a genome-wide analysis of rare copy-number variation (CNV) in 1124
autism spectrum disorder (ASD) families, each comprised of a single proband, unaffected …

Transcriptomic analysis of autistic brain reveals convergent molecular pathology

…, J Mill, RM Cantor, BJ Blencowe, DH Geschwind - Nature, 2011 - nature.com
Autism spectrum disorder (ASD) is a common, highly heritable neurodevelopmental condition
characterized by marked genetic heterogeneity 1 , 2 , 3 . Thus, a fundamental question is …

Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap

…, S Horvath, DH Geschwind - Science, 2018 - science.org
The predisposition to neuropsychiatric disease involves a complex, polygenic, and pleiotropic
genetic architecture. However, little is known about how genetic variants impart brain …

Dentate granule cell neurogenesis is increased by seizures and contributes to aberrant network reorganization in the adult rat hippocampus

…, WY Timothy, RT Leibowitz, DH Geschwind… - Journal of …, 1997 - Soc Neuroscience
The dentate granule cell layer of the rodent hippocampal formation has the distinctive property
of ongoing neurogenesis that continues throughout adult life. In both human temporal …