Since the earliest examination of cellular structures, biologists have been fascinated by
observing cells using light microscopy. The advent of fluorescent labeling technologies plus the …

ADDITION of the β-hydroxy-β-methylglutaryl-CoA (HmG-CoA) reductase inhibitor lovastatin
to human HEK cells transfected with the amyloid precursor protein (APP) reduces …

Cellular processes depend on the fidelity of intracellular membrane traffic. Lipids, proteins,
receptor ligands and solute molecules are trafficked to distinct compartments within the cell …

Early endosome-to-trans-Golgi network (TGN) transport is organized by the retromer complex.
Consisting of cargo-selective and membrane-bound subcomplexes, retromer coordinates …

SNX-BAR proteins are a sub-family of sorting nexins implicated in endosomal sorting. Here,
we establish that through its phox homology (PX) and Bin–Amphiphysin–Rvs (BAR) domains…

CD63 is a lysosomal membrane protein that belongs to the tetraspanin family. Its carboxyterminal
cytoplasmic tail sequence contains the lysosomal targeting motif GYEVM. Strong, …

The selective export of proteins and lipids from the endoplasmic reticulum (ER) is mediated
by the coat protein complex II (COPII) that assembles onto the ER membrane. In higher …

Transport of proteins between the endoplasmic reticulum and Golgi apparatus is mediated
by two distinct membrane coat complexes, COPI and COPII. Genetic, biochemical and …

Rab GTPases control vesicle movement and tethering membrane events in membrane
trafficking. We used the 38 human Rab GTPase activating proteins (GAPs) to identify which of the …

The first membrane trafficking step in the biosynthetic secretory pathway, the export of proteins
and lipids from the endoplasmic reticulum (ER), is mediated by COPII-coated vesicles. In …