User profiles for David M. Kern

David M Kern

- Verified email at its.jnj.com - Cited by 2476

David M. Kern

- Verified email at modextx.com - Cited by 784

The hydration of carbon dioxide

DM Kern - Journal of Chemical Education, 1960 - ACS Publications
Kern … Two 70-ml portions of 0.01 M NaOH are … reactions respectively) with a buffer of
known pH, and follow with a large excess of 4 M amine after the desired reaction time …

[HTML][HTML] Cryo-EM structure of SARS-CoV-2 ORF3a in lipid nanodiscs

DM Kern, B Sorum, SS Mali, CM Hoel… - Nature structural & …, 2021 - nature.com
SARS-CoV-2 ORF3a is a putative viral ion channel implicated in autophagy inhibition,
inflammasome activation and apoptosis. 3a protein and anti-3a antibodies are found in infected …

T cell activation and senescence predict subclinical carotid artery disease in HIV-infected women

…, X Xue, P Hunt, R Karim, DM Kern… - Journal of Infectious …, 2011 - academic.oup.com
Background. Individuals infected with human immunodeficiency virus (HIV) have increased
risk of cardiovascular events. It is unknown whether T cell activation and senescence, 2 …

Structural brain alterations in schizophrenia following fetal exposure to the inflammatory cytokine interleukin-8

…, S Vinogradov, WS Kremen, JH Poole, DM Kern… - Schizophrenia …, 2010 - Elsevier
BACKGROUND: Maternal infection during pregnancy has been repeatedly associated with
increased risk for schizophrenia. Nevertheless, most viruses do not cross the placenta; …

Understanding CKD among patients with T2DM: prevalence, temporal trends, and treatment patterns—NHANES 2007–2012

B Wu, K Bell, A Stanford, DM Kern, O Tunceli… - BMJ Open Diabetes …, 2016 - drc.bmj.com
Objective To describe the estimated prevalence and temporal trends of chronic kidney disease
(CKD) treatment patterns, and the association between CKD and potential factors for type …

Structure of SARS-CoV-2 M protein in lipid nanodiscs

KA Dolan, M Dutta, DM Kern, A Kotecha, GA Voth… - Elife, 2022 - elifesciences.org
SARS-CoV-2 encodes four structural proteins incorporated into virions, spike (S), envelope (E),
nucleocapsid (N), and membrane (M). M plays an essential role in viral assembly by …

[HTML][HTML] Cryo-EM structure of the SARS-CoV-2 3a ion channel in lipid nanodiscs

DM Kern, B Sorum, SS Mali, CM Hoel, S Sridharan… - BioRxiv, 2020 - ncbi.nlm.nih.gov
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the virus that causes the
coronavirus disease 2019 (COVID-19). SARS-CoV-2 encodes three putative ion channels: E…

[HTML][HTML] HARmonized Protocol Template to Enhance Reproducibility of hypothesis evaluating real-world evidence studies on treatment effects: a good practices report …

…, G Crane, W Goettsch, W Hua, S Kabadi, DM Kern… - Value in Health, 2022 - Elsevier
Objectives Ambiguity in communication of key study parameters limits the utility of real-world
evidence (RWE) studies in healthcare decision-making. Clear communication about data …

Cryo-EM structures of the DCPIB-inhibited volume-regulated anion channel LRRC8A in lipid nanodiscs

DM Kern, SC Oh, RK Hite, SG Brohawn - Elife, 2019 - elifesciences.org
Hypoosmotic conditions activate volume-regulated anion channels in vertebrate cells. These
channels are formed by leucine-rich repeat-containing protein 8 (LRRC8) family members …

Rates of antipsychotic drug prescribing among people living with dementia during the COVID-19 pandemic

…, KY Liu, X Lin, C Yin, S Fortin, DM Kern… - Jama …, 2023 - jamanetwork.com
Importance Concerns have been raised that the use of antipsychotic medication for people
living with dementia might have increased during the COVID-19 pandemic. Objective To …