Amyloid diseases are global epidemics with profound health, social and economic implications
and yet remain without a cure. This dire situation calls for research into the origin and …

The protein α-synuclein is the main component of Lewy bodies, the neuron-associated
aggregates seen in Parkinson disease and other neurodegenerative pathologies. An 11-residue …

α-Synuclein (aSyn) fibrillar polymorphs have distinct in vitro and in vivo seeding activities,
contributing differently to synucleinopathies. Despite numerous prior attempts, how …

The nomenclature committee of the International Society of Amyloidosis (ISA) meets every
second year to discuss and formulate recommendations. The conclusions from the discussion …

The ISA Nomenclature Committee met electronically before and directly after the XVII ISA
International Symposium on Amyloidosis, which, unfortunately, had to be virtual in September …

A pathway from the natively unfolded microtubule-associated protein Tau to a highly structured
amyloid fibril underlies human Tauopathies. This ordered assembly causes disease and …

Nature uses a limited set of metabolites to perform all of the biochemical reactions. To increase
the metabolic capabilities of biological systems, we have expanded the natural metabolic …

Dozens of proteins are known to convert to the aggregated amyloid state. These include fibrils
associated with systemic and neurodegenerative diseases and cancer, functional amyloid …

The aggregation of proteins into structures known as amyloids is observed in many
neurodegenerative diseases, including Alzheimer's disease. Amyloids are composed of pairs of …

The hidden world of amyloid biology has suddenly snapped into atomic-level focus, revealing
over 80 amyloid protein fibrils, both pathogenic and functional. Unlike globular proteins, …