Background O-fucose is added to cysteine-rich domains called thrombospondin type 1 repeats
(TSRs) by protein O-fucosyltransferase 2 (POFUT2) and is elongated with glucose by β3-…

Reduced amino acid availability attenuates mRNA translation in cells and helps to extend
lifespan in model organisms. The amino acid deprivation–activated kinase GCN2 mediates …

N-Glycosylation has long been linked to protein folding and quality control in the endoplasmic
reticulum (ER). Recent work has shown that O-linked glycosylation and the corresponding …

The Integrated Stress Response (ISR) helps metazoan cells adapt to cellular stress by
limiting the availability of initiator methionyl-tRNA for translation. Such limiting conditions …

Inhibitors of apoptosis (IAPs) family of genes encode baculovirus IAP-repeat domain-containing
proteins with antiapoptotic function. These proteins also contain RING or UBC domains …

Protein O-fucosyltransferase 2 (POFUT2) is an essential enzyme that fucosylates serine and
threonine residues of folded thrombospondin type 1 repeats (TSRs). To date, the …

The Integrated Stress Response (ISR) refers to a signaling pathway initiated by stress-activated
eIF2α kinases. Once activated, the pathway causes attenuation of global mRNA …

PERK is an endoplasmic reticulum (ER) transmembrane sensor that phosphorylates eIF2α
to initiate the Unfolded Protein Response (UPR). eIF2α phosphorylation promotes stress-…

Reproduction is an energy-intensive process requiring systemic coordination. However, the
inter-organ signaling mechanisms that relay nutrient status to modulate reproductive output …

ADAMTSL2 mutations cause an autosomal recessive connective tissue disorder, geleophysic
dysplasia 1 (GPHYSD1), which is characterized by short stature, small hands and feet, …