User profiles for Dominic Holland
 | Dominic HollandUniversity of California, San Diego Verified email at ucsd.edu Cited by 15191 |
A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer's disease
Late-onset Alzheimer’s disease is a prevalent age-related polygenic disease that accounts
for 50–70% of dementia cases. Currently, only a fraction of the genetic variants underlying …
for 50–70% of dementia cases. Currently, only a fraction of the genetic variants underlying …
Genome-wide association study identifies 30 loci associated with bipolar disorder
…, S Herms, M Hipolito, P Hoffmann, D Holland… - Nature …, 2019 - nature.com
Bipolar disorder is a highly heritable psychiatric disorder. We performed a genome-wide
association study (GWAS) including 20,352 cases and 31,358 controls of European descent, …
association study (GWAS) including 20,352 cases and 31,358 controls of European descent, …
What is normal in normal aging? Effects of aging, amyloid and Alzheimer's disease on the cerebral cortex and the hippocampus
What can be expected in normal aging, and where does normal aging stop and pathological
neurodegeneration begin? With the slow progression of age-related dementias such as …
neurodegeneration begin? With the slow progression of age-related dementias such as …
One-year brain atrophy evident in healthy aging
An accurate description of changes in the brain in healthy aging is needed to understand
the basis of age-related changes in cognitive function. Cross-sectional magnetic resonance …
the basis of age-related changes in cognitive function. Cross-sectional magnetic resonance …
Efficient correction of inhomogeneous static magnetic field-induced distortion in Echo Planar Imaging
Single-shot Echo Planar Imaging (EPI) is one of the most efficient magnetic resonance imaging
(MRI) acquisition schemes, producing relatively high-definition images in 100 ms or less. …
(MRI) acquisition schemes, producing relatively high-definition images in 100 ms or less. …
Genome-wide analyses for personality traits identify six genomic loci and show correlations with psychiatric disorders
Personality is influenced by genetic and environmental factors 1 and associated with mental
health. However, the underlying genetic determinants are largely unknown. We identified …
health. However, the underlying genetic determinants are largely unknown. We identified …
[HTML][HTML] Genetic assessment of age-associated Alzheimer disease risk: development and validation of a polygenic hazard score
Background Identifying individuals at risk for developing Alzheimer disease (AD) is of utmost
importance. Although genetic studies have identified AD-associated SNPs in APOE and …
importance. Although genetic studies have identified AD-associated SNPs in APOE and …
Critical ages in the life course of the adult brain: nonlinear subcortical aging
Age-related changes in brain structure result from a complex interplay among various
neurobiological processes, which may contribute to more complex trajectories than what can be …
neurobiological processes, which may contribute to more complex trajectories than what can be …
Alzheimer Disease: Quantitative Structural Neuroimaging for Detection and Prediction of Clinical and Structural Changes in Mild Cognitive Impairment1
…, JC Roddey, DJ Hagler Jr, D Holland… - Radiology, 2009 - pubs.rsna.org
Purpose: To use structural magnetic resonance (MR) images to identify a pattern of regional
atrophy characteristic of mild Alzheimer disease (AD) and to investigate whether presence …
atrophy characteristic of mild Alzheimer disease (AD) and to investigate whether presence …
Regional rates of neocortical atrophy from normal aging to early Alzheimer disease
Objective: To evaluate the spatial pattern and regional rates of neocortical atrophy from
normal aging to early Alzheimer disease (AD). Methods: Longitudinal MRI data were analyzed …
normal aging to early Alzheimer disease (AD). Methods: Longitudinal MRI data were analyzed …