Polyploid cells have genomes that contain multiples of the typical diploid chromosome
number and are found in many different organisms. Studies in a variety of animal and plant …

The past decade of research on Drosophila stem cells and niches has provided key insights.
Fly stem cells do not occupy a special "state" based on novel "stem cell genes" but …

Polyploidy, resulting from the duplication of the entire genome of an organism or cell, greatly
affects genes and genomes, cells and tissues, organisms, and even entire ecosystems. …

Polyploid cells, which contain more than two genome copies, occur throughout nature.
Beyond well-established roles in increasing cell size/metabolic output, polyploidy can also …

Background Reestablishing epithelial integrity and biosynthetic capacity is critically
important following tissue damage. The adult Drosophila abdominal epithelium provides an …

Morphogenesis involves the interplay of different cytoskeletal regulators. Investigating how
they interact during a given morphogenetic event will help us understand animal development…

Endopolyploidy arises during normal development in many species when cells undergo
endocycles—variant cell cycles in which DNA replicates but daughter cells do not form. Normally…

Cadherin–catenin complexes, localized to adherens junctions, are essential for cell–cell
adhesion. One means of regulating adhesion is through the juxtamembrane domain of the …

The adult Drosophila hindgut was recently reported to contain active, tissue-replenishing
stem cells, like those of the midgut, but located within an anterior ring so as to comprise a …

The proto-oncogenic kinase Abelson (Abl) regulates actin in response to cell signaling.
Drosophila Abl is required in the nervous system, and also in epithelial cells, where it regulates …