Our appreciation of the physiological functions of estrogens and the mechanisms through
which estrogens bring about these functions has changed during the past decade. Just as …

During the past decade there has been a substantial advance in our understanding of estrogen
signaling both from a clinical as well as a preclinical perspective. Estrogen signaling is a …

Nuclear receptors (NRs) are master regulators of transcriptional programs that integrate the
homeostatic control of almost all biological processes. Their direct mode of ligand regulation …

Transcriptional regulation of gene expression by nuclear receptors requires negatively and
positively acting cofactors. Recent models for receptor activation propose that certain …

Nuclear receptors (NRs) comprise a family of ligand inducible transcription factors. To
achieve transcriptional activation of target genes, DNA-bound NRs directly recruit general …

In contrast with the class A heat stress transcription factors (HSFs) of plants, a considerable
number of HSFs assigned to classes B and C have no evident function as transcription …

The orphan receptor LRH-1 and the oxysterol receptors LXRα and LXRβ are established
transcriptional regulators of lipid metabolism that appear to control inflammatory processes. …

Using reporter assays in tobacco protoplasts and yeast, we investigated the function of the
acidic C-terminal activation domains of tomato heat stress transcription factors HsfA1 and …

Birth presents a metabolic challenge to cardiomyocytes as they reshape fuel preference from
glucose to fatty acids for postnatal energy production 1 , 2 . This adaptation is triggered in …

The activation function 2/ligand-dependent interaction between nuclear receptors and their
coregulators is mediated by a short consensus motif, the so-called nuclear receptor (NR) box…