Background We present the results of EGASP, a community experiment to assess the state-of-the-art
in genome annotation within the ENCODE regions, which span 1% of the human …

Alternative splicing changes are frequently observed in cancer and are starting to be
recognized as important signatures for tumor progression and therapy. However, their functional …

The Ensembl ( http://www.ensembl.org/ ) database project provides a bioinformatics
framework to organise biology around the sequences of large genomes. It is a comprehensive …

Alternative splicing is regulated by multiple RNA-binding proteins and influences the
expression of most eukaryotic genes. However, the role of this process in human disease, and …

Ensembl ( http://www.ensembl.org/ ) is a bioinformatics project to organize biological
information around the sequences of large genomes. It is a comprehensive source of stable …

When targeting promoter regions, small interfering RNAs (siRNAs) trigger a previously
proposed pathway known as transcriptional gene silencing by promoting heterochromatin …

Intron retention (IR) occurs when an intron is transcribed into pre-mRNA and remains in the
final mRNA. We have developed a program and database called IRFinder to accurately …

To understand the biology and evolution of ruminants, the cattle genome was sequenced to
about sevenfold coverage. The cattle genome contains a minimum of 22,000 genes, with a …

The BioMart Community Portal ( www.biomart.org ) is a community-driven effort to provide a
unified interface to biomedical databases that are distributed worldwide. The portal provides …

The functional capacity of cells is defined by the transcriptome. Many recent studies have
identified variations in the transcriptome of tumors due to alternative splicing changes, as well …