User profiles for Eldad Zacksenhaus
 | Eldad ZacksenhausProfessor of Medicine, University of Toronto Verified email at utoronto.ca Cited by 18464 |
[HTML][HTML] Characterisation of retinoblastomas without RB1 mutations: genomic, gene expression, and clinical studies
…, C Massey, R Godbout, Z Jiang, E Zacksenhaus… - The lancet …, 2013 - thelancet.com
Background Retinoblastoma is the childhood retinal cancer that defined tumour-suppressor
genes. Previous work shows that mutation of both alleles of the RB1 retinoblastoma …
genes. Previous work shows that mutation of both alleles of the RB1 retinoblastoma …
pRb controls proliferation, differentiation, and death of skeletal muscle cells and other lineages during embryogenesis.
E Zacksenhaus, Z Jiang, D Chung… - Genes & …, 1996 - genesdev.cshlp.org
Mice deficient for the RB gene (RB-/-), prior to death at embryonic day 14.5, show increased
cell death in all tissues that normally express RB1: the nervous system, liver, lens, and …
cell death in all tissues that normally express RB1: the nervous system, liver, lens, and …
Identification of tumorsphere-and tumor-initiating cells in HER2/Neu-induced mammary tumors
JC Liu, T Deng, RS Lehal, J Kim, E Zacksenhaus - Cancer research, 2007 - AACR
A variety of human malignancies, including breast cancer, are thought to be organized in a
hierarchy, whereby a relatively minor population of tumor initiating cells (TIC) is responsible …
hierarchy, whereby a relatively minor population of tumor initiating cells (TIC) is responsible …
[HTML][HTML] Rb deletion in mouse mammary progenitors induces luminal-B or basal-like/EMT tumor subtypes depending on p53 status
…, TF Lane, CM Perou, E Zacksenhaus - The Journal of …, 2010 - Am Soc Clin Investig
Breast cancer is a highly heterogeneous disease, with several different subtypes being
characterized by distinct histology, gene expression patterns, and genetic alterations. The tumor …
characterized by distinct histology, gene expression patterns, and genetic alterations. The tumor …
Cooperation between Pik3ca and p53 Mutations in Mouse Mammary Tumor Formation
…, W Wang, KL Wright, TF Lane, E Zacksenhaus… - Cancer research, 2011 - AACR
PIK3CA, which codes for the p110α catalytic subunit of phosphatidylinositol 3-kinase, is one
of the most frequently mutated genes in human breast cancer. Here, we describe a mouse …
of the most frequently mutated genes in human breast cancer. Here, we describe a mouse …
[HTML][HTML] RB1 deficiency in triple-negative breast cancer induces mitochondrial protein translation
…, A Schimmer, E Zacksenhaus - The Journal of …, 2016 - Am Soc Clin Investig
Triple-negative breast cancer (TNBC) includes basal-like and claudin-low subtypes for
which no specific treatment is currently available. Although the retinoblastoma tumor-suppressor …
which no specific treatment is currently available. Although the retinoblastoma tumor-suppressor …
The ets transcription factor Fli-1 in development, cancer and disease
Y Li, H Luo, T Liu, E Zacksenhaus, Y Ben-David - Oncogene, 2015 - nature.com
Friend leukemia virus-induced erythroleukemia-1 (Fli-1), an E26 transformation specific (ETS)
transcription factor, was isolated a quarter century ago through a retrovirus mutagenesis …
transcription factor, was isolated a quarter century ago through a retrovirus mutagenesis …
[HTML][HTML] Molecular stratification within triple-negative breast cancer subtypes
…, Z Jiang, Y Ben-David, JR Woodgett, E Zacksenhaus - Scientific reports, 2019 - nature.com
Triple-negative breast cancer (TNBC) has been subdivided into six distinct subgroups: basal-like
1 (BL1), basal-like 2 (BL2), mesenchymal (M), mesenchymal stem–like (MSL), …
1 (BL1), basal-like 2 (BL2), mesenchymal (M), mesenchymal stem–like (MSL), …
[PDF][PDF] Lunatic fringe deficiency cooperates with the Met/Caveolin gene amplicon to induce basal-like breast cancer
…, K Yoon, N Gaiano, V Ling, J Beyene, E Zacksenhaus… - Cancer cell, 2012 - cell.com
Basal-like breast cancers (BLBC) express a luminal progenitor gene signature. Notch
receptor signaling promotes luminal cell fate specification in the mammary gland, while …
receptor signaling promotes luminal cell fate specification in the mammary gland, while …
Combined deletion of P ten and p53 in mammary epithelium accelerates triple‐negative breast cancer with dependency on e EF 2 K
…, M Tsao, TW Mak, E Zacksenhaus - EMBO molecular …, 2014 - embopress.org
The tumor suppressors Pten and p53 are frequently lost in breast cancer, yet the consequences
of their combined inactivation are poorly understood. Here, we show that mammary‐…
of their combined inactivation are poorly understood. Here, we show that mammary‐…