Background Effective targeted therapy for sepsis requires an understanding of the
heterogeneity in the individual host response to infection. We investigated this heterogeneity by …

Background Host responses during sepsis are highly heterogeneous, which hampers the
identification of patients at high risk of mortality and their selection for targeted therapies. In this …

To assess factors influencing the success of whole-genome sequencing for mainstream
clinical diagnosis, we sequenced 217 individuals from 156 independent cases or families …

Treatment of severe COVID-19 is currently limited by clinical heterogeneity and incomplete
description of specific immune biomarkers. We present here a comprehensive multi-omic …

Sepsis arises from diverse and incompletely understood dysregulated host response processes
following infection that leads to life-threatening organ dysfunction. Here we showed that …

Background Sepsis continues to be a major cause of death, disability, and health-care
expenditure worldwide. Despite evidence suggesting that host genetics can influence sepsis …

Improved risk stratification and prognosis prediction in sepsis is a critical unmet need. Clinical
severity scores and available assays such as blood lactate reflect global illness severity …

Rationale: Heterogeneity in the septic response has hindered efforts to understand
pathophysiology and develop targeted therapies. Source of infection, with different causative …

Although alterations in myeloid cells have been observed in COVID-19, the specific underlying
mechanisms are not completely understood. Here, we examine the function of classical …

… Black and red dots indicate genes in the Davenport signature and … (E) Reference map of
sepsis based on the Davenport … We refer to the 7-gene set as the Davenport signature and to …