Background Allergic inflammation involves the sensitization of naive CD4 + T cells to allergens,
resulting in a T H 2-skewed inflammatory response. Although antigen presentation by …

The hematopoietic system produces a large number of highly specialized cell types that are
derived through a hierarchical differentiation process from a common stem cell population. …

Methylation of nonhistone proteins is emerging as a regulatory mechanism to control protein
function. Set7 (Setd7) is a SET-domain-containing lysine methyltransferase that methylates …

Accumulating evidence suggests that the regulation of gene expression by histone lysine
methylation is crucial for several biological processes. The histone lysine methyltransferase …

There is a great deal of interest in determining what regulates the generation of classically
activated (M1) vs alternatively activated (M2) macrophages (Mφs) because of the opposing …

Inflammatory bowel disease (IBD) pathogenesis is associated with dysregulated CD4 + Th
cell responses, with intestinal homeostasis depending on the balance between IL-17–…

Intestinal tumorigenesis is a result of mutations in signaling pathways that control cellular
proliferation, differentiation, and survival. Mutations in the Wnt/β-catenin pathway are …

Fibrosis is the result of dysregulated tissue regeneration and is characterized by excessive
accumulation of matrix proteins that become detrimental to tissue function. In Crohn’s disease…

1. Abstract 2. Introduction 3. The structure and expression of SHIP 4. The phenotype of the
SHIP knockout mouse 5. SHIP’s mechanism of action 6. The biological roles of SHIP 7. The …

The SH2-containing inositol-5′-phosphatase, SHIP (or SHIP1), is a hematopoietic-restricted
phosphatidylinositide phosphatase that translocates to the plasma membrane after …